摘要
目的 通过检测肿瘤性腹水、结核性腹水和肝硬化腹水患者的细胞间粘附分子 1(I CAM 1)和P$C选择素 (P selection)水平 ,探讨其鉴别炎性和非炎性腹水的意义。方法 采用酶联免疫吸附法 (ELISA)检测 2 9例肿瘤性腹水、2 0例结核性腹膜炎腹水和 13例肝硬化性腹水患者腹水的ICAM 1和P 选择素水平。结果 肿瘤性腹水ICAM 1水平为 (63 .5 4± 3 7.68)ng/L ,结核性腹水水平为 (12 3 .85± 41.85 )ng/L ,肝硬化腹水水平为 (3 5 .95± 11.5 0 )ng/L ,肿瘤性腹水P 选择素水平为 (3 .0 3± 1.2 6)ng/L ,结核性腹水水平为 (4 .2 6± 1.63 )ng/L ,肝硬化腹水水平为 (2 .72±1.49)ng/L。结核性腹水患者ICAM 1和P 选择素水平明显高于肿瘤性腹水 (P <0 .0 5 )和肝硬化性腹水 ,两者水平在肿瘤性腹水和肝硬化腹水之间的差异无显著性 (P >0 .0 5 )。结论 ICAM 1和P 选择素的表达与机体炎症反应被激活有关 ,结核性腹膜炎患者腹水中ICAM 1和P 选择素水平明显增高 ,检测腹水中ICAM 1和P
Objective To evaluate the significance of P-selectin and intercellular adhesion molecule-1(ICAM-1)in differentiating inflammatory and noninflammatory ascites.Methods P-selectin and ICAM-1 in ascitic fluid were detected in 20 patients with tuberculous peritonitis,29 with neoplasm,13 with cirrhosis by ELISA.Results The levels of ICAM-1 were(63.54±37.68)ng/L,(123.85±41.85)ng/L and(35.95±11.50)ng/L in neoplastic,tuberculous and cirrhosis ascites,respectively.The levels of P-selectin were(3.03±1.26)ng/L,(4.26±1.63)ng/L and(2.72±1.49)ng/L in above three ascites.ICAM-1 and P-selectin in patients with tuberculous peritonitis were much higher than those of neoplastic ascites(P< 0.05)and cirrhotic ascites,but there was no difference between neoplastic and cirrhotic ascites.Concussion ICAM-1 and P-selectin expression is related to inflammatory reaction activation.So detecting P-selectin and ICAM-1 in ascites might be helpful in differentiating inflammatory and no inflammatory ascites.
出处
《临床内科杂志》
CAS
北大核心
2003年第10期526-528,共3页
Journal of Clinical Internal Medicine
关键词
腹水
细胞间粘附分子
P-选择素
Ascites
Intercellular adhesion molecule-1
P-selection
