摘要
目的 :研究妊高征患者母血及胎盘组织中卵泡休止素 (FS)水平变化的临床意义。方法 :采用固相双夹心酶联免疫吸附 (ELISA)法测定妊高征组 (轻度 4例、中度 4例、重度 12例 )及正常妊娠组 (34例 )孕妇血清以及胎盘组织 (两组各 10例 )FS含量。结果 :妊高征组血清FS水平低于正常妊娠组 (P <0 .0 0 1) ;重度妊高征组血清FS水平低于轻中度妊高征组 (P<0 .0 5 ) ;妊高征组胎盘组织FS含量低于正常妊娠组 (P<0 .0 0 1) ;两组血清FS水平与胎盘组织FS含量呈显著的直线相关关系 (P <0 .0 5 )。结论 :FS下降可能参与妊高征的发生、发展。
Objective: Our aim was to study changes of levels of follistatin (FS) in maternal serum and placenta in pregnancy induced hypertension syndrome(PIH) and the clinical significance. Methods: Level of FS was measured by using ELISA in 20 patients with PIH and 34 women in normal pregnancy. Results: Level of FS in maternal serum in PIH group was significantly reduced compared with that in normal pregnancy group (P<0.001); and was lower in severe PIH group than that in mild to moderate PIH group (P<0.01); Level of FS in placenta was lower in PIH group than that in normal pregnancy group (P<0.01). In both PIH group and normal pregnancy group, level of FS in maternal serum was related with that of placenta (P<0.05). Conclusion: Follistatin may involve in the progression of PIH. Level of FS in maternal serum can be used as an index for the assessment of placenta function.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2003年第5期450-452,共3页
Journal of China Medical University
关键词
妊娠并发症
心血管
高血压
卵泡休止素
激活素
pregnancy complications
cardiovascular
hypertension
follistatin
activin
