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抗SARS冠状病毒药物研究与开发途径

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摘要 目的 探讨抗SARS冠状病毒药物开发途径。方法 回顾SARS冠状病毒感染机制和病毒的生物学机制以及SARS临床特征和治疗策略。结果 从病毒复制、感染的特点以及人体对该病毒的反馈机制和特点推测疫苗、免疫调节剂、反义核酸药物和特异性酶抑制剂、非特异性抗病毒小分子药物以及预防传播药物等是开发抗SARS CoV药物的可能途径。结论 目前特异性抗病毒药物的开发仍然是研究人员必须面对的一大挑战,短时期内寻找和筛选出有较高疗效的抗SARS冠状病毒药物有相当大的困难,但通过多种途径、针对多个靶点开发抗病毒药物对于SARS的临床治疗将产生积极意义。
出处 《中药新药与临床药理》 CAS CSCD 2003年第5期349-353,共5页 Traditional Chinese Drug Research and Clinical Pharmacology
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