摘要
以非放射性(Dig—HBV—DNA 探针)分子杂交技术,检测了银川地区405例 HBsag携带人群中的 HBV—DNA。阳性率为34.81%(男性40.32%高于女性30.14%,P<0.05),且随年龄的增长而极急速地下降(P<0.005),回汉民族间无明显差异。HBsAg 的滴度与HBV—DNA 的检出率呈正相关(γ_s=0.999,P<0.01)HBsAg 的滴度至≥1:256时,HBV—DNA 的检出率可高达100%。作者等认为;以 HBsAg 的定量滴度来判定其传染性有一定的参考价值;滴度在1:64～1:128时需加强治疗管理,≥1:256时应视为病毒复制的标志,并具有较强的传染性。
Reporting theHBV-DNA distributi- on in 405 HBsAg carried Yinchuan District inhabitants,determined by the non-radioactivity molecular hybr- idization techniqlle.The positive de- tecble rate were 34.81 per cent(40.32 per cent in males and 34.14 per cent in females).These rates fell dramatic- ally as their age groups became hig- her and higher(p<<0.005).There existed a positive correlation(r(?)=0.999, P<0.001),between titers of HBsAg and the detectable rates of HBV- DNA;When the titer of HBsAg was higher or equal to 1:256,the detecta- ble rate went up to 100 per cent Thus, it is thought consultatively,that we could also indirectly titers;hence, judgethe infectivity of the due HBV virus by analyzing the dynamic qua- ntitative HBsAg when the HBsAg tit- ers range between 1:64 and 1:128, the carrier patients must be treate p- romptly & carefully;when the titer becomes higher or equal to 1:256,it could serve as a marker of virus re- plication and a signal of stronger vi rus infectivity.
出处
《宁夏医学杂志》
CAS
1992年第6期321-323,共3页
Ningxia Medical Journal
关键词
乙型肝炎
表面抗原
分子杂交
DNA
Hybridization
Mo lecular probe technics
DNA
viral
Hepatitis B surface antigens/anal
Virus replication
Infection
