摘要
目前已经克隆了 3种甘丙肽受体 (GalR1,GalR2 ,GalR3) ,它们都是与G蛋白相偶联的受体 . 3种甘丙肽受体的氨基酸序列、药理学特性以及第二信使系统各不相同 .GalR1/ 3受体可以抑制腺苷酸环化酶并可以激活钾通道 ,GalR2受体可以激活磷脂酶C并增加胞内钙离子浓度 .用RNA印迹、反转录PCR以及原位杂交等技术对上述 3种甘丙肽受体在人、大鼠和小鼠中的分布进行了研究 ,发现它们具有不同的分布特征 。
Three types of galanin receptor (GalR1, GalR2, GalR3) have been cloned to date, and identified to be G-protein coupled receptors. These three galanin receptors show differences in their amino acids sequences, pharmacological properties, as well as in the second messenger system. Activation of GalR1/3 induces inhibition on adenylyl cyclase and to activate K+ channels, while activation of GalR2 leads to the stimulation of phospholipase C and intracellular Ca2+ mobilization. The distribution of the three galanin receptors in human, rats and mice have been investigated by Northern blot, RT-PCR and in situ hybridization. The different distribution of the galanin receptor indicates that galanin participates a broad range of physiological activities.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2003年第5期698-701,共4页
Progress In Biochemistry and Biophysics
关键词
甘丙肽受体
G蛋白偶联受体
第二信使
中枢神经系统
galanin receptor
G-protein coupled receptor
second messenger
the central nervous system
