摘要
用放射免疫法测定急性肾炎(n=31)、慢性肾炎(n=19)和肾病(n=23)患儿血浆β-内啡肽(β-EP)、环磷腺苷(cAMP)和环鸟苷(cGMP)含量,并以年龄、性别相当的22例正常儿童作对照。结果表明:血肽β-EP 在急性肾炎(7.29±3.04ng/L,P<0.01)、慢性肾炎(6.11±2.53ng/L,P<0.05)和肾病(6.11±2.53ng/L,P<0.05)明显高于正常对照(4.66±1.87ng/L);cAMP 在急性肾炎高于正常对照(32.93±12.61对20.14±5.35nmol/L,P<0.01),cGMP 则在慢性肾炎(9.91±4.85nmol/L,P<0.01)和肾病(8.60±2.87nmol/L,P<0.05)高于正常对照(6.64±2.67nml/L)。急性肾炎β—EP 与 cAMP 升高呈正相关 r=0.4017,P<0.05)慢性肾炎和肾病β-EP 与 cGMP 升高呈正相关(r=0.3418,P<0.05和 r=0.3392,P<0.05)。作者等认为,联合测定血肽β-EP、cAMP 和 cGMP 含量对诊断和鉴别诊断儿童急、慢性肾炎和肾病有一定的临床意义。
plasma radioimmunoas- say for β-endorphin(β-EP),cAMP & cGMP was conducted on 73 nephropathy children consisting of acute glomerulo- nephritis(n=31),chronic glomerulo- ephritis(n=19)& nephrosis(n=23), and 22 healthy children served as con- trol.In acute glomerulonephrits,β-Ep (7.29±3.04ng/L,P<0.01)&cAMP(32.93 ±12.61nmol/L,P<0.01);in chronic glomemulonephritis,β-Ep(6.11±2.53ng/ L,P<0.05)&cGMP(9.91±4.85nmol/L, P<0.01)and in nephrosis,β—EP(6.11± 2.53ngl/L,P<0.05)& eGMp(8.60±2.87 nmol/L,P<0.05),were higher than con- trol(β-Ep 4.66±1.87ng/L,cAMP 20.14 ±5.35nmol/L & cGMP 6.64±2.67nmol/ L),β-EP level correlated with cAMP (r=0.4017,P<0.05)in the acute glo- merulonephrtis,correlated with cGMP in the chronic glomerulonephritis(r= 0.3418,P<0.05)& hephrosis(r=0.3392, P<0.05).These combined assaying data support the assumption that of plasma β-EP,cAMP & eGMP is of cliniecal significance in differential in diagnosis of the various kinds of nephropathy children.
出处
《宁夏医学杂志》
CAS
1992年第5期275-278,共4页
Ningxia Medical Journal
关键词
肾小球肾炎
诊断
儿童
内啡肽类
Glomerulonephritis/diaq
Neqkrosis/diag
Child
Endorphinsi
Adenosinecyclic monophate
Guauosine cyclic monophosphate
Radioimunrnnoassay
