摘要
用生物化学、免疫化学和放射免疫方法,对70例肺癌、24例肺结核、20例肺心病患者及61名正常人进行了8项血清肿瘤标记物检测;并利用电子计算机对检测结果进行了逐步判别分析,探讨各肿瘤标记物在肺癌辅助诊断方面的意义。结果,肺癌 LSA、α_1-AG、α_1-AT、β_2-MG、SF 和 IgMCIC 水平升高,EA 光密度增加;肺结核α_1-AT、β_2-MG、SF、IgG 和 IgMCIC 水平也升高;肺心病α_1-AT、β_2-MG 及 SF 水平升高。肺癌手术和化学治疗后 LSA 降低。未分化小细胞肺癌 IgMCIC 水平高于肺鳞癌。肺癌 CIC 以 IgMCIC 为主。逐步判别分析结合综合判断分析后的数据提示,联合检测 EA、LSA、α_1-AT 及 SF 对肺癌的辅助诊断价值较大。
The serum levels of eight tumor markers were assayed in 70 patients with lung cancer(LC), 24 patients with pulmonary tuberculo- sis,20 patients with cot pulmonale, and 61 healthy adults by biochemical, immunochemical and radioimmunoassay methods.The resultant data underwent a stepwise discriminant analysis (SDA)by computer in order to as- sess the value of this method in diag- nosing patients with(LC),indicating that in LC,the levels of LSA,α_1- AG,α_1-AT,β_2-MG,SF,and IgM CIC rose markedly,and the optical densi- ty of EA increased.Levels of α_1-AT, β_2-MG,SF and Igm CIC rose in pati- ents with pulmonary tuberculosis;le- vels of α_1-AT,β_2-MG and SF rose in cor pulmonale.After chemical and operative therapy for LC,the levels of LSA declined significantly.The level of IgM CIC in oat cell LC was significantly higher than that in squa- mous cell LC.The category of CIC in LC was mainly IgM CIC.Results of SDA and comprehensive analysis sug- gested that the combination assay of serum EA,LSA,α_1-AT and SF is of adjuvant value in diagnosis of LC.
出处
《宁夏医学杂志》
CAS
1992年第4期203-207,共5页
Ningxia Medical Journal
关键词
肺肿瘤
诊断
肿瘤标记物
Lung neoplasms/dia
Carcinoma
Tumor markers biological
(?)iscriminant analysis
EA/diag
Si-
alic acids/diag
Alpha Ⅰ-antitrypsin/diag
Ferritin/diag
