摘要
目的:观察中西医结合治疗对乙肝后肝硬化失代偿期的抗肝纤维化作用。方法:本课题采用随机、对照的方法,纳入我院2013年1月~2013年11月确诊为乙肝后肝硬化失代偿期患者100例随机平均分为两组,观察组采用中医辨证论治联合核苷类似物阿德福韦酯,对照组单纯采用阿德福韦酯治疗。两组均服药48周,并在服药期间要求患者禁饮酒吸烟,注意饮食起居,观察结束后两组患者继续服用阿德福韦酯胶囊。观察两组患者治疗后的治疗效果及症状表现,治疗前后的肝纤维化指标和上腹部彩超结果。结果:两组患者经治疗后,症状体征均有改善;肝纤维化指标降低,彩超检查结果均较治疗前有显著性差异(P<0.05);治疗组的有效率为86%,对照组的有效率为62%;所检测观察指标的组间相比也具有统计学差异(P<0.05)。结论:两组患者经过治疗后疗效均有改善,在核苷类似物的基础上联合中医辨证论治,抗肝纤维化的效果显著,值得临床广泛推广应用。
Objective: This paper aimed to study integrative treatment for decompensated cirrhosis of liver fibrosis. Methods: 100 patients were exerted randomized,controlled way and divided into two groups in our hospital from January 2013 to November 2013 diagnosed with decompensated cirrhosis after hepatitis B,50 cases in the observation group,using traditional Chinese medicine combined with nucleoside analogues,50 cases in the controlled group,only using adefovir. Both groups were taking 48 weeks,and patients require medication during the smoking ban alcohol,pay attention to diet,after the end of the two groups were observed to continue taking adefovir capsules. Treatment and symptoms observed two groups of patients after treatment,liver fibrosis and upper abdominal ultrasound results before and after treatment. Results: The two groups of patients after treatment,symptoms and signs were improved; reduces liver fibrosis,there was a significant difference( P < 0. 05) compared with the results of ultrasound examination before treatment; the effective rate of the observation group was 86%,the effective rate of the controlled group was 62%; detected between observed indicators also had significant difference compared( P < 0. 05).Conclusions: Two groups of patients are improved after treatment efficacy,based on the joint righting nucleoside analogues combine with traditional Chinese medicine,anti-fibrotic effect is significant,is worthy of wider dissemination of research.
出处
《四川中医》
2015年第8期64-67,共4页
Journal of Sichuan of Traditional Chinese Medicine
