摘要
目的总结低分子右旋糖酐引起过敏反应的临床特点,分析其原因,以便为安全有效地使用低分子右旋糖酐提供指导。方法1997年8月～2002年12月,收治470例病人中,常规应用低分子右旋糖酐治疗,发生过敏反应11例。根据瑞典关于右旋糖酐过敏反应的分级标准,Ⅰ级6例,Ⅱ级4例,Ⅲ级1例。所有病人均给予相应对症(Ⅰ、Ⅱ级)和抢救(Ⅲ级)治疗。结果过敏反应症状在1～3周内消失而治愈,无死亡和后遗症病例。结论低分子右旋糖酐可以引起不同程度的过敏反应,对于轻型过敏反应,停止低分子右旋糖酐的输入,对症治疗即可治愈;严重过敏反应,必须采取有效的治疗措施以抢救病人生命。
Objective To analyze the clinical characteristics and mechanisms of dextran -40induced anaphylactic reactions(DIAR),and to provide instructions for the safely administration of dextran40.Methods From August1997to December2002,470patients were treated with dextran-40,11of them developed anaphylactic reactions(9men and2women).According to the standards issued by Sweden,the reactions were classified as having GradeⅠ6cases,GradeⅡ4cases,and GradeⅢ1case.The patients were treated accordingly.Results The clinical symptoms disappeared in1～3weeks,all the patients were cured,no died or developed sequelae patient .Conclusion The symptoms of DIAR usually occur after using dextran-40for 5～7days.Interruption of the infusion and symptomatic therapy should be adequate for mild reactions;Once severe reactions occur,various effective treatments should be applied in order to save life.
出处
《实用手外科杂志》
2003年第3期143-144,共2页
Journal of Practical Hand Surgery
