摘要
目的 探讨血栓前体蛋白 (TPP)在心脏机械瓣膜置换术后抗凝治疗监测中的意义 ,及制定术后抗凝治疗的合理方案。方法 比较抗凝组 (6 0例 )和对照组 (2 0例 )的国际标准化比率 (INR)、TPP ,并比较抗凝组中有、无房颤的病人华法林用量、INR和TPP。对抗凝组病人TPP和INR的关系作一元线性回归分析 ,比较各组的INR和血浆TPP浓度。结果 抗凝组与对照组相比 ,TPP低、INR高。抗凝组有房颤者的血浆TPP浓度高于窦性心律者。线性回归分析结果表明 ,TPP和INR无明显相关性。出血病人的血浆TPP浓度明显低于正常高限 (6 μg/ml)。结论 TPP是心脏机械瓣置换术后抗凝治疗理想的辅助监测指标。术后有房颤心律者的血栓栓塞危险性增加。抗凝治疗应同时检测INR和TPP。
Objective: To investigate the role of thrombus precursor protein (TPP) in the monitoring of anticoagulation after mechanical heart valve replacement. Methods: TPP and INR were compared between the coagulant group and control group. In the coagulant group, TPP and INR were also compared between the patients with atrial fibrillation and the patients without atrial fibrillation. The relationship between TPP levels and INR levels in 60 cases of anticoagulated patients was analyzed by linear regression. Results: It was found that the anticoagulant therapy could effectively decrease the level of TPP and increase the level of INR. In the anticoagulant group, the patients with atrial fibrillation had higher TPP level than other patients. No significant relationship was found between TPP levels and INR levels. TPP level in the patients with bleeding complications was far lower than 6 μg/ml. Conclusion: TPP is a very valuable monitoring marker assisting INR. Patients with atrial fibrillation may require higher anticongulant intensity. INR and TPP should be tested at the same time in the patients receiving oral anticoagulation after mechanical heart valve replacement.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2003年第4期218-220,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
