摘要
我们最近的实验工作证明艾灸大鼠“神阙”能够减轻应激引起的胃粘膜损伤,具有胃粘膜保护作用。考虑到当前国内外大量研究资料表明前列腺素在胃粘膜保护中具有十分重要的作用,以及胃肠道内存在的内源性阿片肽可以通过增加胃粘膜血流而调节胃肠功能,我们用放射免疫方法观察了艾灸过程中大鼠胃粘膜前列腺素含量的变化,用ABC免疫组化方法观察了艾灸对大鼠胃粘膜β-内啡肽样免疫反应细胞的影响。
RIA and ABC -immunohistochemical methods were used to study the influence of moxibustion on gastric mucosal PGE_2 content and β-endorphine -like immune active cells respectively. The results were: 1、In rats undergoing moxibustion at 'Shengquc' for three weeks, the PGE_2 content in the gastric mucosa increased significantly; 2、Moxibustion at 'Shengque'for two and three weeks caused a significant increase of β-ednorphine -like immune active cells. These variation had a time coordination with the emergence of gastric mucosal protection of moxibustion. The results suggested that moxibustion may give its role in gastric mucosal protection through increasing the content of PGE_2 and intrinsic opium peptide in gastric mucosa.
