摘要
目的 探讨双水平正压通气在Ⅱ型呼吸衰竭中的治疗作用。方法 将 5 7例慢性阻塞性肺病 (COPD)合并Ⅱ型呼吸衰竭患者随机分为BiPAP呼吸机治疗组 (治疗组 ,2 1例 )和常规治疗组 (对照组 ,3 1例 ) ,监测其治疗前、治疗后 2小时、治疗后 5天的血气变化 ,观察临床情况的变化及并发症的发生 ,对结果分别进行对比。结果 经治疗后 2小时 ,呼吸机治疗组呼吸频率、心率较对照组明显改善 ,但收缩血压、体温及外周血白细胞计数比较差异无显著性。治疗组pH、PaO2 、Pa CO2 、HCO2 -指标经BiPAP呼吸机治疗后明显改善 (P <0 .0 1)。除了 3例出现腹胀 ,6例有鼻罩部皮肤损伤 ,2例患者胸闷、气喘加重外 ,其余未发生并发症。结论 双水平正压通气能明显改善Ⅱ型呼吸衰竭患者的低氧血症及高碳酸血症 ,并发症少 ,其疗效优于常规治疗方法 。
Objective To explore the effects of noninvasive ventilation on pulmonary gas exchange during acute hypercapnic exacerbations of chronic obstructive pulmonary disease.Methods 57 COPD patients with acute severe hypercapnic respiratory failure were randomly divided experimental group(21 cases)and control group(31 cases).Measurements of pulmonary gas exchange were done:(1)breathing spontaneously(baseline); (2) after 2 h and 5 days of BiPAP using a full face mask.Results The experimental group were significantly improvement in PaO 2,a fall in PaCO 2 and in pH and HCO 2 - after 2 h and 5 days by BiPAP(P<0.05).The heart rate and breath rate were significantly decrease after 2 h of BiPAP(P<0.05).The side effect was limited.Conclusion BiPAP could be proposed as a effective method in COPD patients with Ⅱ type respiratory failure.
出处
《临床内科杂志》
CAS
北大核心
2003年第9期466-468,共3页
Journal of Clinical Internal Medicine
