摘要
目的 探讨胆囊癌组织中bcl 2蛋白表达的情况及其表达强度与术后生存期的关系。方法 采用免疫组织化学方法链霉素亲生物素蛋白的过氧化酶连结法 (SP法 )结合微波抗原修复 ,对 40例原发性胆囊癌组织及 40例胆囊良性病变组织进行bcl 2蛋白的表达研究 ,结合术后生存情况进行分析。结果 40例原发性胆囊癌组织中bcl 2蛋白表达阳性率为 65 .0 0 % (2 6/ 40 ) ,40例胆囊良性病变组织中阳性率为 5 .0 0 % (2 / 40 ) ,两者差异有非常显著性 (P <0 .0 1)。分化程度高bcl 2蛋白过表达的患者术后生存期长。bcl 2蛋白低表达 ,组织分化低的患者术后生存期短 ,预后差。结论 bcl 2蛋白表达与胆囊癌发生有关。bcl
Objective To study the expression of bcl-2 in human gallbladder carcinoma and the relationship between the expression intensity and survival time.Methods The expression of bcl-2 protein in 40 cases of human gallbladder carcinoma and 40 cases of benign gallbladder lesions were detected by using SP method in combination with antigen microwave methods.Results The positive rate of the expression of bcl-2 protein in gallbladder carcinoma was 65.00 % (26 /40),significantly higher than that in benign gallbladder lesions (5.00 %,P<0.01).The expression of bcl-2 protein was closely related to tumor differentiation.Conclusion The bcl-2 protein expression was related to the pathogenesis of human gallbladder carcinoma.bcl-2 protein expression may be used as a promising predictor for the prognosis of patients with gallbladder carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2003年第9期809-810,共2页
Chinese Journal of Experimental Surgery
