摘要
报道10例家族性高胆固醇血症(FH)患者血浆中过氧化脂质(AHP)含量平均值为2.06±0.51△D233/ml血浆,比正常组(1.28±0.15)明显升高。患者组血浆各种脂蛋白组分中,只有低密度脂蛋白(LDL-C)明显升高,极低密度脂蛋白(VLDL-C)在两组之间无显著差异,高密度脂蛋白(HDL-C)反而明显减少,因此推测FH患者的AHP升高主要是由于LDL含量升高。配对分析了正常人与患者LDL组分对CuCl_2氧化的敏感性,发现FH患者的LDL对氧化的敏感度亦有增高的趋势。
The plasma lipid peroxide levels (Acylhydroperoxid, AHP) weremeasured in 10 patients with familial hypercholesterolemia (FH). The meanvalue±SD was found to be 2.06±0.51 △D233/ml plasma, significantly higherthan that in normal controls (1.28±0.15). Among the lipoprotein fractions, onlylow density lipopro ein (LDL-C) was significantly increased in FH group, whileHDL-C was significantly decreased and VLDL-C had no significant difference.It was deduced that the increase of AHP was mainly due to increased LDL. Itwas also found that LDL in FH patients might have enhanced susceptibility toCuCl_2 oxidation than LDL in normal controls.
关键词
脂蛋白类
过氧化脂质
高胆固醇血症
hypercholesterolemia, familial
lipoproteins, LDL
lipid peroxides
human
