摘要
目的 了解革兰氏阴性杆菌的流行分布及耐药谱的变化 ,为临床合理选用抗生素提供依据。 方法 对我院 2 0 0 0～ 2 0 0 2年三年间革兰氏阴性杆菌耐药性结果进行回顾性统计分析。 结果 革兰氏阴性杆菌三年检出率分别为6 4 .3%、5 8.7%、5 3.7% ;肠杆菌科细菌对头孢噻肟的耐药率上升 5 .4 %～ 13.8% ,大肠埃希菌对环丙沙星的耐药率上升13.6 % ,铜绿假单胞菌对亚胺培南耐药率上升 8.4 % ,阿米卡星耐药率变化不大 ;产 ESBL s的大肠埃希菌和克雷伯氏菌分别从 2 1.5 %、2 0 .2 %上升到 2 8.8%、31.7%。 结论 三年间临床分离致病菌都以革兰氏阴性杆菌为主 ,革兰氏阴性杆菌检出率逐年下降 ;肠杆菌科细菌比例下降 ,不动杆菌属和嗜麦芽假单胞菌比例增加 ;抗生素的耐药性普遍增加 ;ESBL
Objective To study the distribution of the Gram-Negative bacillus and the change of its tolerance pattern,provide a reasonable selection for antibiotic in clinic. Methods Make a retrospective analysis for the tolerance of Gram-Negative bacillus results in 2000～2002 in our hospital. Result The detection out ratio of Gram-Negative bacillus was 64.3%,58.7%,53.7% in three years respectively.The enterobacter bacteria tolerance ratio for cefetaxime increased 5.4%～13.8%,the Escherichia Coli tolerance ratio for ciprofloxacin increased 13.6%,the Pseudomonas aeruginosa tolerance ratio for Imipenem increased 8.4%.The tolerance change for Amikacin was not significant,the tolerance ratio for birth ESBLs Escherichia Coli and Klebsiellar increased from 21.5% to 28.8%,20.2% to 31.7% respectively. Conclusion The Gram-Negative bacillus was the major bacteria isolated in three years.The detection out ratio for Gram-Negative bacillus and enterobacter bacteria ratio had decreased,the ratio for Acinetobacter and Pseudomonas maltophilia increased.The tolerance to antibiotics had increased widely.The detection out ratio for ESBLs had significantly increased.
出处
《实用预防医学》
CAS
2003年第4期497-499,共3页
Practical Preventive Medicine
关键词
革兰氏阴性杆菌
耐药性
抗生素
Gram-Negative bacillus
Drug tolerance
Antibiotic
