摘要
用移动平均法测定了氯羟吡啶对大、小鼠的经口 LD_(50),分别为7183mg/kg 和400mg/kg。在小鼠胚胎转移微核试验中,160mg/kg 氯羟吡啶18h 采样组的孕鼠胎肝血嗜多染红细胞平均微核率极显著(P<0.01)高于吐温组(阴性对照组).50mg/kg 能引起小鼠骨髓细胞多倍体发生率和小鼠精于畸形率极显著或显著增高(P<0.01和 P<0.05).10,30和100mg/kg3剂量组的平均每个细胞姐妹染色单体交换率均极显著(P<0.01)高于吐温组。在显性致死试验中,雄鼠每天一次灌胃100mg/kg 氯羟吡啶,连续5天,第3周交配的孕鼠平均活胎数显著低于吐温组;每个孕鼠平均早期死胎数显著高于吐温组;突变指数极显著(P<0.01)高于吐温组。据此,可初步认为氯羟吡啶对小鼠的体细胞和生殖细胞有弱致突变作用.
In the fetal liver of mice at 18h after treatment with 160mg/kg clopidol,the frequency ofmicronuclcated PCEs(6.5±0.5%)was much higher(P<0.01)than the negative control( 2.6±0.24%).The clopidol at 50mg/kg could develop obviously more polyploids(3%)and significantly highersperm abnormalities(5.34%)as compared with the concerned control(0.4% and 3.28% respectively).Theclopidol at doses of 10,30 and 160 mg/kg produced 4.27±0.30,5.23±0.30 and 5.96±0.30 SCEs per cellrespectively,which increased significantly(P<0.01)over the control one(2.88±0.17).The males dosed dai-ly with 100mg/kg clopidol for five consecutive days mated with six group females serially for six weeks.Among these females,the third group yielded 10.7±0.6 living embryos each pregnant female,which wasapparently lower(P<0.05)than the control one(12.2+ 0.4)and the death embryos 1.22±0.29 increasedsignificantly(P<0.05)over the control one(0.44±0.20).Its mutagenic index 10.1 was significantly higher(P<0.01)than the control(3.4).The present research suggested that clopidol was slightly mutagenic.
出处
《南京农业大学学报》
CAS
CSCD
北大核心
1992年第2期89-95,共7页
Journal of Nanjing Agricultural University
关键词
氯羟吡啶
致突变性
毒性
clopidol
mutagcnicity
transplacental micronucleus
SCE
dominant lethal
