摘要
目的 调查河南省0～6岁儿童脑性瘫痪(CP)的患病率、临床类型、相关病因及合并症的状况。方法 2001年1～12月,采用随机整群抽样方法,对河南省郑州市(金水区、二七区、邙山区)、洛阳市涧西区、济源市、原阳县、新野县、唐河县、太康县、虞城县10个市、区、县1995年1月1日至2000年12月31日出生的0～6岁儿童进行了调查。应用SPSS 10.0软件,进行统计学分析。结果 共调查0～6岁儿童434920人,男231111人,女203809人,男:女=1.13:1;发现CP患儿582例,男374例,女208例,男:女=1.80:1;患病率1.07‰～2.38‰,平均患病率为1.58‰。CP的各种类型中,痉挛型最多见,为331例(56.9％),肌张力低下型123例(21.1％),混合型44例(7.6％),强直型39例(6.7％),共济失调型31例(5.3％),震颤型8例(1.4％),手足徐动型6例(1.0％)CP的病因学调查中,以出生时窒息及缺氧缺血性脑病为多见,占38.3％(223例),双胎20.1％(117例),早产和(或)低体重16.8％(98例),母孕早期感染11.9％(69例),脑出血9.3％(54例)。以上均是引起CP的明显相关因素(与健康儿童组对比,均产<0.05),而新生儿期高胆红素血症、感染及胎粪吸入等,与CP的发生无明显相关性(P>0.05)。CT或MRI检查异常率70.0％(297/424例)。有合并症者占67.8％(394例),合并智力低下者49.0％(285例),语?
Objective To investigate the prevalence,distribution of different types and etiologic factors and complications of children cerebral palsy(CP)in Henan Province. Methods From January to December 2001, by randomly cluster sampling,children of 0-6 years were investigated in ten cities and counties, including three districts-Jinshui, Erqi, Mangshan-in Zhengzhou City;Jianxi district in Luoyang Citys;Jiyuan City and such counties as Yuanyang, Xinye, Tanghe,Taikang, Yucheng,etc. The causes, clinical types and CT/MRI features of all cases were analyzed. Results There were 582 CP patients among 434920 children investigated, the total prevalence rate of CP being 1. 58‰. Of these 582 CP cases, spastic type was 331 cases( 56.9%), hypotonic type 123(21.1%), mixture type 44 (7.6 % ), tonic type 39 (6.7%),ataxia type 31 (5.3%),tremor type 8(1.4%),athetosis type 6(1.0%). As to the causes of CP,infants who had asphyxia or hypoxic- ischemic encephalopathy (HIE) in birth were 223 cases(38.3% ),twins 117(20.1%) .babies born preterm or with low birth weight 98(16.8%),maternal infections during primal pregnancy 69(11.9% ), and in-traventricular hemorrhage(IVH) 54(9.3%). The complications presented in 394 cases(67.8%) ,of which mental retardation (MR) accounted for 49.0% ,language disorder 35.4% ,epilepsy 17.0% .hearing disorder 11.9% and vision disorder 6.5%. Conclusion The average prevalence of CP in Henan province was 1.58%o. The spastic type is the mcxst common type of CP,and MR is the main complication. Asphyxia and HIE,premature and low birth weight infants,maternal infections during primal pregnancy and twins are high-risk factors.
出处
《中国实用儿科杂志》
CSCD
北大核心
2003年第8期464-467,共4页
Chinese Journal of Practical Pediatrics
基金
河南省科技攻关项目(981170815)
