摘要
目的 :研究三磷酸胞苷二钠 (CTP)防治急性有机磷中毒 (AOPP)周围神经病变的效果。方法 :AOPP导致呼吸衰竭机械通气者 12 3例 ,在常规治疗的基础上分 2组 :CTP组 6 2例 ,以CTP12 0mg加入 5 %葡萄糖 2 5 0ml内静滴 ,每天 1次 ,14d为 1疗程。对照组 6 1例 ,静滴 5 %葡萄糖2 5 0ml,每天 1次 ,14d为 1疗程。单盲对照。结果 :CTP组机械通气时间 2 92 .8± 6 4 .8h ;迟发性周围神经病变 3例。对照组机械通气时间 4 0 6 .2± 10 3h ;迟发性周围神经病变 11例。P均 <0 .0 1,有极显著性差异。结论 :CTP用于治疗AOPP能够缩短机械通气时间 ,减少迟发性周围神经病变发生率。
Objective: To study the effects of cytidine disodium triphosphate (CTP) in treating patients with peripheral nervous lesion caused by acute organophosphorus poisoning (AOPP). Methods: 123 patients in ICU with respiratory failure caused by AOPP were divided into 2 groups on the basis of routine treatment. 62 cases received 120mg CTP in 5% Glucose 250ml IV drip once per day for 14 days. 61 cases as the control group were administered 5% glucose 250ml once per day for 14 days. Single blinded control was adopted. Results: The mechanical ventilation time of CTP group was 292.8 ± 64.8 hours, and 3 cases developed tardive peripheral nervous lesion, while in the control group the mechanical ventilation time were 406.2 ± 103 hours and 11 patients developed tardive nervous lesion. There were significant differences between 2 groups ( P <0.01). Conclusion: CTP can shorten the mechanical ventilation time and lower the incidence of developing nervous lesion in patients with AOPP.
出处
《内科急危重症杂志》
2003年第3期132-133,共2页
Journal of Critical Care In Internal Medicine
关键词
急性有机磷中毒
周围神经病变
三磷酸胞苷二钠
防治
Acute organophosphorus poisoning Peripheral nervous lesion Cytidine disodium triphosphate
