摘要
目的 探讨头孢噻肟钠静滴用药时细菌内毒素检查的方法。方法 按照中国药典 2 0 0 0版二部方法进行实验。结果 结合临床实际应用情况将头孢噻肟钠内毒素限值确定为 0 .0 8EU .mg 1较为合适。结论 可为该药静滴时采用的细菌内毒素检查提供参考依据。
Objective TO set up a reasonable limit of bacterial endotoxin for cefotaxime sodiumfor injection and establish a rapid and accurate method for examining bacterial endotoxin. Methods The total limit of the bacterial endotoxin in the combined medicines was used as the limit of the bacterial endotoxin for cefotaxime sodiumfor injection .The interference test was conducted by using the different batches in order to establish the maximum noninterference concentration and the best testing concentration. Results The most suitable limit of bacterial endotoxin in cefotaxime sodiumfor injection was 0.08EU.mg-1. Conclusions This method for bacterial endotoxin was accurate and reliable and replace the pyrogen test.
出处
《合肥医学院学报》
2003年第3期228-229,共2页
Journal of Zunyi Medical University
关键词
头孢噻肟钠
鲎试剂
细菌内毒素
cefotaxime sodiumfor
tachypleus Amebocyle lysate
Bacterial endotoxin
