摘要
观察中药肺岩宁 (黄芪、白术等 )对血管内皮生成因子 (VEGF)分泌的影响及抗晚期非小细胞肺癌侵袭转移的临床疗效。将 ( 91例 )病例分为化疗组 ( 3 1例 )、肺岩宁 +化疗组 (综合组 3 2例 )、肺岩宁组 ( 2 8例 )。化疗组化疗后对症治疗 ,综合组化疗前后服肺岩宁方 ,肺岩宁组单纯服用肺岩宁 ;治疗前后测定血清VEGF水平 ,观察患者原发瘤灶、转移灶变化和新转移灶出现情况 ,评价生活质量和毒副反应。疗程 3～ 4个月。结果 :治疗后原发病灶瘤体综合组与化疗组比较有显著性差异 (P <0 0 5 ) ;转移灶瘤体综合组治疗后转移灶的增大显著低于化疗组 (P <0 0 5 ) ;新转移灶肺岩宁组和综合组淋巴结转移和远处转移的发生情况显著低于化疗组 (P <0 0 5 ) ;治疗前后相比 ,化疗组患者血清VEGF水平表现出上升趋势 ,肺岩宁组和综合组治疗后血清VEGF水平显著下降 (P <0 0 5 )。实验采用C5 7BL/ 6小鼠 ,接种Lewis肺癌细胞株 ,随机分为对照组、化疗组、肺岩宁组、综合组。实验结果 :用免疫组化法测定肿瘤切片的VEGF表达 ,小鼠肿瘤VEGF的表达。结论 :益气养精、解毒抗癌的肺岩宁具有抗肺癌侵袭转移的作用 ,减少VEGF分泌 ,抑制血管生成 ,可能是肺岩宁抗肺癌生长转移的机理之一。
To observe the influence of 'Feiyanning Decoction' on the secretion of vascular endothelial growth factor (VEGF) and its clinical effects on late non-small cell lung cancer (NSCLC) metastasis, 91 subjects were randomized into group A, B and C. Group A (31 cases) was treated by chemotherapy, group B (32 cases) by chemotherapy plus 'Feiyanning Decoction', and group C by simple 'Feiyanning Decoction', with a course of 3-4 months. The level of serum VEGF, tumor focus and metastasis, life quality and toxic-negative effects were detected before and after treatment. Moreover, C57BL/6 mice inoculated with Lewis lung cancer cell strain were treated by chemotherapy or / and 'Feiyanning Decoction'; and the VEGF expression was assayed. Results: After treatment, the tumor decreased more obviously in group B than in group A (P<0.05); the metastatic tumor was smaller in group B than in group A (P<0.05); the metastatic rate of lymph nodes was lower in group B than in group C (P<0.05); after chemotherapy, the level of VEGF rose, but after treatment, it reduced obviously (P<0.05). Conclusion: 'Feiyanning Decoction' can prevent the metastasis, reduce the secretion of VEGF and inhibit the angiopoiesis, and eventually to treat the lung cancer.
出处
《上海中医药大学学报》
CAS
2003年第3期18-22,共5页
Academic Journal of Shanghai University of Traditional Chinese Medicine
