摘要
本文用Hela细胞乳酸脱氢酶释放法测定了19例慢性乙肝病人外周血NK、ADCC活性以及rIL-2对它们的影响。结果表明,正常人外周血PBL经rIL-2500u/ml预培养18小时后NK、ADCC活性均显著升高(P<0.01,P<0.05);慢性迁延性肝炎病人(CPH)ADCC对rIL-2呈明显增强反应(P<0.05),但NK活性无明显改变;慢性活动性肝炎病人(CAH)则NK活性对rIL-218小时培养后有明显的增强(P<0.05),ADCC活性无变化;11例CAH PBL经rIL-2500u/ml预处理4小时其NK活性即有非常显著的升高(P<0.001),而且这种增强作用在rIL-2500u/ml以内随rIL-2浓度增大而增强。IFN-α和rIL-2具有协同增强乙肝病人NK、ADCC活性之作用。
In this study, the effect of rIL-2 on NK, ADCC activities of patients with chronic hepatitis was investigated. The results indicate that the NK or ADCC activities of patients with CAH or CPH have normal responses to rIL-2. These give clinical physician the basic evidence for rIL-2 used to treat patients with chronic hepatitis.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1992年第3期173-176,共4页
Immunological Journal
