摘要
目的 :探讨新生儿脐血红细胞平均体积 (MCV)和红细胞平均血红蛋白 (MCH)与地中海贫血的关系。方法 :用血细胞计数仪测定新生儿脐血的MCV和MCH ,用醋酸纤维薄膜电泳检测脐血的HbBart’s,用跨越断裂点PCR(gap PCR)法检测东南亚缺失型α 地中海贫血 1基因。结果 :地中海贫血组的新生儿脐血MCV和MCH明显小于正常新生儿组 (P <0 .0 1) ,符合小细胞低色素性贫血。结论
Objective:To study the relationship between mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH) of umbilical blood and thalassemia.Methods:MCV and MCH,Hb Bart's and alpha thalassemia 1 gene were determined by automatic analyzer,electrophoresis and gap PCR respectively in 35 neonates with thalassemia and 46 normal newborns.Results:MCV and MCH in patients were significantly lower than those in normal controls( P <0.01).Conclusion:MCV and MCH of umbilical blood might be important clues to the diagnosis of thalassemia.
出处
《广东医学院学报》
2003年第4期335-336,共2页
Journal of Guangdong Medical College
