摘要
目的 :探讨血清一氧化氮 (NO)和肿瘤坏死因子 α(TNF α)在小儿急性肾小球肾炎 (AGN)中的作用及其相互关系。方法 :分别采用硝酸还原酶法和放射免疫法测定AGN患儿 (急性期组 2 5例 ,恢复期组 11例 )和 16例正常对照者血清NO和TNF α水平。结果 :AGN急性期组和恢复期组血清NO和TNF α水平较对照组均有显著性升高 (P <0 .0 1) ,急性期组血清NO水平显著高于恢复期组 (P <0 .0 1) ;且急性期组和恢复期组血清NO水平与血浆TNF α含量均呈中度正相关 (P <0 .0 1,r=0 .6 7,P <0 .0 1,r=0 .6 9)。结论 :NO和TNF
Objective:To investigate the role of nitric oxide(NO)and tumor necrosis factor α(TNF α)in the pathogenesis of acute glomerulonephritis(AGN).Methods:Serum NO and TNF α levels were detected by nitrate reductase method and radioimmunoassay respectively in 36 patients with AGN(25 cases of acute stage and 11 cases of convalescent stage)and 16 normal controls.Results:NO and TNF α contents in AGN children were obviously superior to those in controls ( P < 0.01) ,and NO concentrations in acute stage of AGN were high as compared with those in convalescent stage( P <0 01).There were positive correlations between NO and TNF α in acute and convalescent stages ( r =0.67, P <0.01;r=0.69, P <0.01).Conclusion:Both NO and TNF α could be implicated in the pathogenesis of AGN.
出处
《广东医学院学报》
2003年第4期333-334,共2页
Journal of Guangdong Medical College
