摘要
对2-碘-9-苄基嘌呤与有机锡试剂RSnBu_3之间的Stille偶合反应以及2-乙烯基-9-苄基嘌呤中的乙烯基的亲核加成和环加成反应进行了研究,合成出了一系列新的2位取代的嘌呤衍生物.化合物的结构均经元素分析、~1H NMR、^(13)C NMR和MS确证.提出2-乙烯基-9-苄基嘌呤与苯硫酚的反应机理为氧化加成而非亲核加成,采用单晶X射线衍射法对主要产物的结构进行了确认.
The Stille coupling reaction between 2-iodo-9-benzylpurine and RSnBu3 and the nucleophilic addition and cycloaddition of 2-vinyl-9-benzylpurine were studied. A series of new 2-substituted purined-erivatives were synthesized and characterized by elemental analysis, 1H NMR, 13C NMR and MS. It was demonstrated that the reaction mechanism between 2-vinyl-9-benzylpurine and benzenethiol was oxidative addition rather than nucleophilic addition. The structure of the main product was determined by single-crystal X-ray method.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2003年第9期1592-1598,共7页
Chemical Journal of Chinese Universities
基金
山东省优秀中青年科学家科学研究奖励基金(批准号:02135107)
