摘要
采用免疫组织化学 (S- P)法对 37例非小细胞肺癌组织中的尿激酶型纤溶酶原激活物 (urokinase- type plasminogenactivator,u PA)进行检测、分析。结果发现肺癌组织中 u PA表达的总阳性率为 5 4 .0 5 % (2 0 /37) ,其中肿块大于 3cm组阳性表达率为 6 6 .6 7% (18/2 7) ,显著高于肿块小于 3cm组的阳性表达率 2 0 .0 0 % (2 /10 ,P<0 .0 5 ) ;淋巴结转移组阳性表达率为88.89% (8/9) ,显著高于无淋巴结转移组的 4 2 .86 % (12 /2 8,P<0 .0 5 ) ,认为 u PA的表达与非小细胞肺癌的侵袭转移特性有关 。
This paper is to study the significance of urokinase type plasminogen activator (uPA) expression in non small cell lung cancer (NSCLC). Expression of uPA in 37 cases of NSCLC was examined by immunohistochemistry.uPA was positive in 54.05%(20/37) patients with NSCLC and the level was higher in bigger tumors(>3 cm,66.67%,18/27) than those in smaller tumors(<3 cm,20.00%,2/10, P <0.05). Expression level of uPA was higher in N 1(88.89%,8/9) than in N 0 stage (42.86%, 12/28, P <0.05).The expression of uPA was associated with invasion and metastasis of NSCLC,which may be a potential prognostic marker for NSCLC.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第8期S004-S005,共2页
Academic Journal of Second Military Medical University
