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垂体瘤的分子生物学研究进展

Progress in molecular biology of pituitary tumor
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摘要 垂体瘤来源于垂体前叶细胞 ,是常见的颅内肿瘤。它因其细胞增殖及内分泌特性而表现出各种的生物学行为。以往 ,对于垂体瘤的研究主要集中在组织学和超微结构上 ;随着分子生物学的发展对垂体瘤的认识已有了很大的提高。本文从染色体变异、癌基因及抑癌基因的突变。 Pituitary tumors, originated from homoral adenohypophyseal cells, are very common in intracranial neoplasms. They are characterized by a wide range of biological behavioral related to hormoral and proliferative activities. Previous pituitary adenoma studies mainly devoted to histological and ultrastructural classification with immunohistochemical techniques. Molecular biology allowed new approaches, especially concerning the pathogenesis and progression. This article reviews the progress of these researches regarding chromosomes, oncogenes, antioncogenes, transgenic animal models and genetic therapy.
作者 姜福全 周晓平
机构地区 第二军医大学长海医院神经外科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2003年第8期896-898,共3页 Academic Journal of Second Military Medical University
关键词 垂体瘤 分子生物学 研究进展 染色体变异 癌基因 抑癌基因 分子生物学 pituitary tumor chromosome gene
分类号 R736.4 [医药卫生—肿瘤]
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参考文献27

  • 1王清,惠国桢,蔺玉昌,鲁晓杰,俞文华,吴思荣,吴智远.垂体瘤遗传变异的初步研究[J].癌症,2002,21(10):1120-1123. 被引量：2
  • 2Pernicone P J, Scheithauer BW, Sebo TJ,et al. Pituitary carcinoma:a clinicopathological study of 15 cases [J]. Cancer, 1997,79(4) :804-812.
  • 3Zhuang Z, Ezzat SZ, Vortmeyer AO, et al. Mutation of the MEN1 tumor suppressor gene in pituitary adenomas[J]. Cancer Res,1997,57(24): 5446-5451.
  • 4Larsen JB,Sehroder HD,Sorensen AG,et al. Simple numerical chromosome aberrations characterize pituitary adenomas[J].Cancer Genet Cytogenet,1999,114(2) : 144-149.
  • 5Bello M J, Campos JM, Kusak ME, et al. Chromosomal abnomalities in pituitary adenomas [J]. Cancer Genet Cytogenet,2001,124(1):76-79.
  • 6Bettio D,Rizzi N,Giardino D,et al. Cytogenetic study of pituity adenomas [J]. Cancer Genet Cytogenet, 1997,98(2) : 131-136.
  • 7Farrell WE,Clayton RN. Molecular biology of pituitary adenomas[J]. Front Neuroendocrinol,2000,21(3) : 174-198.
  • 8Haymard BE, Barlier A, Korbonits M, et al. Imprinting of the G(s) alpha gene GNAS1 in the pathogenesis of acromegaly[J]. J Clin Invest,2001,107(6) :R31-R36.
  • 9Horwitz GA, Miklovsky I, Heaney AP, et al. Human pituitary tumor transforming gene (PTTG1) motif suppresses prolactin expression[J]. Mol Endocrinol, 2003,17(4) : 600-609.
  • 10Zhang X, Horwitz GA, Prezant TR, et al. Pituitary tumour transforming gene(PTTG) expression in pituitary adenomas[J]. J Clin Endocrinol Metab, 1999,84(2) : 761-767.

二级参考文献10

  • 1[1]Finelli P, Ginrdio D, Rizzi N, et al. Non-random trisomy of chromosomes 5,8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study [J]. Int J Cancer, 2000,86:344- 350.
  • 2[2]Bettio D, Rizzi N, Giardino D, et al. Cytogenetic study of pituitary adenomas [J]. Cancer Genet Cytogenet,1997,98:131- 136.
  • 3[3]Pihan GA, Doxsey SJ. The mitotic machinery as a source of genetic instability in cancer [J]. Semin Cancer Biol, 1999,9:289- 302.
  • 4[4]Sen S. Aneuploidy and cancer [J]. Curr Opin Oncol,2000,12:82- 88.
  • 5[5]Butler MG, Sciadini M, Hedges LK, et al. Chromosome telomere integrity of human solid neoplasms [J]. Cancer Genet Cytogenet, 1996,86:50- 53.
  • 6[6]Li YS, Fan YS, Asmstrong RS. Endoreduplication and telomeric association in a choroids plexus carcinoma [J]. Cancer Genet Cytogenet, 1996,87:7- 10.
  • 7[7]Larsen JB, Schroder HD, Sorensen AG, et al. Simple numerical chromosome aberrations characterize pituitary adenomas [J]. Cancer Genet Cytogenet, 1999,114: 144- 149.
  • 8[8]Rock J, Babu R, Drumheller T, et al. Cytogenetic findings in pituitary adenoma: results of a pilot study [J]. Surg Neurol, 1993,41:224- 229.
  • 9[9]Bello MJ, de Campos JM, Kusak ME, et al. Chromosomal abnormalities in pituitary adenomas [J]. Cancer Genet Cytogenet, 2001,124:76- 79.
  • 10[10]Di Vinci A,Infusini E, Nigro S, et al. Intratumor distribution of 1p deletions in human colorectal adenocarcinoma is commonly homogeneous: indirect evidence of early involvement in colorectal tumorigenesis [J]. Cancer,1998,83:415- 422.

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第二军医大学学报
2003年 第8期

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