摘要
目的 :探讨经蝶窦手术治疗巨大垂体腺瘤的临床效果。 方法 :采用经蝶窦手术治疗直径大于 4 cm的巨大垂体腺瘤4 6例 ,其中无功能腺瘤 2 4例 ,泌乳素腺瘤 9例 ,生长激素腺瘤 10例 ,促肾上腺皮质激素腺瘤 1例 ,混合性腺瘤 2例。结果 :全组患者 1次手术 31例 ,全切除 8例 (2 5 .8% ) ;分 2次及 2次以上手术者 15例 ,全切除 9例 (6 0 .0 % ) ,分次手术间隔为 6～ 8周。分次手术的肿瘤全切除率高于单次手术者。术后垂体功能低下 2例 ,脑脊液鼻漏 2例 ,术后肢体偏瘫 1例。 1例在术后 2年肿瘤复发。 结论
Objective:To evaluate the therapeutical effect of staged transsphenoidal surgery for giant pituitary adenomas.Methods:Forty six patients with giant pituitary adenomas (more than 4 cm in diameter) were treated.Of the 46 patients,24 were with nonfunctional adenomas,9 with prolactinomas,10 with growth hormone producing adenomas,1 with adrenocorticotropic hormone producing adenoma,and 2 with multiple hormone producing adenomas.Results:Twelve patients were operated on twice,3 patients were operated on 3 times,and the others were operated on only once.The tumors were totally removed in 8 patients for those who underwent operation only once and in 9 for staged surgery group.For the staged surgery,the optimal interval for the next operation was 6 to 8 weeks. The rate of total removal and subtotal removal in the patients underwent staged surgery were higher than those operated only once.The major complications were nasal septum perforation(2 cases) and cerebrospinal fluid rhinorrhea(2 cases).One patient presented with contralateral paresis.There was no mortality.One patient had recurrence 2 years after the operation.Conclusion:Giant pituitary adenomas can be treated safely and effectively with transsphenoidal surgery.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第8期837-839,共3页
Academic Journal of Second Military Medical University
