摘要
颅面畸形是由多病因造成的胚胎发育不良而导致的颅面结构紊乱,是一类较常见的人类先天性疾病,约占所有人类先天性疾病中的1/3。以前人们对遗传和发育在颅面畸形形成中的作用所知有限,最近分子遗传学和发育生物学研究有了重要进展,认识到颅面畸形与遗传缺陷及胚胎发育过程中颅间充质细胞的协调分化和精细选择有关。
Craniofacial malformation is a common kind of human congenital disease caused by embryo hypogenesis from multiple pathogeny, which takes up about one third of congenital diseases. People used to know little about genetics and development of craniofacial malformation. In recent years, with great progress in molecular genetics and development biology, craniofacial malformations are recognized to arise from subtle alternations in the coordinated programme of cell division in cranial mesenchyme and from basic patterning defects.
出处
《中华神经医学杂志》
CAS
CSCD
2003年第4期318-320,F003,共4页
Chinese Journal of Neuromedicine
