12，Shin JM,Besancon M,Prinz C,et al.Continuing development of acid pump inhibitors:site of action of pantoprazole[J].Aliment pharmacol Ther,1994,8(Supp1.1):11
24，Lind T,Cederberg C,Ekenved G,et al.Effect of omeprazole-a gastric proton pump inhibitor-on pentagastrin stimulated acid secretion in man[J].Gut,1983,24:271
35，Brandstrom A,Lindberg P,Bergman NA,et al. Chemical reactions of omeprazole and omeprazole analogues[J].Acta Chem Scand,1989,43:536
46，Nebert DW,McKinnonm RA.Cytochrome p450:evolution and functional diversity[J].In:prog.Liver Dis,1994,12:63
57，Andersson T.Pharmacokinetics,metabolism and interactions of acid pump inhibitors[J]. Clin Pharmacokinet,1996,31(1):9
68，Goldstein JA,Faletto MB,Romkes-Sparks M,et al.Evidence that CYP2C19 is the major(s)-mephenytoin 4'-hydroxylase in humans[J].Biochemistry,1994,33:1743
79，Ishizaki T. Sohn DR、Kobayashi K,et al.Interethnic defferences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in caucasians and orientals[J].Ther Drug Monit 1994,16:214
810，Anderhson T,Miners J,Veronese ME, et al.Identification of human liver cytochrome-P450 isoforms mediating omeprazole metabolism[J].J Clin Pharmacol 1993,36:521
911，Chiba K,Kobayashi K,Manabe K,et al.oxidative metabolism of omeprazole in human liver microsomes:cosegregation with S-mephenytoin 4'-hydroxylation.J.Pharmacol Exp Ther 1993，266:52
1012，Schuitz HU,Hartmann M,Steinijans VW,et al.Lank of influence of pantoprazole[J].Int J Clin Pharmacol Ther Toxicol,1991，29:369
7[2]DOJO M,AZUMA T,SAITO T,et al.Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole),amoxycillin and clarithromycin in Japan[J].Dig Liver Dis,2001,33(8):671 -675.
8[3]SAGAR M,TYBRING G,DAHL M L,et al.Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism[J].Gastroenterology,2000,119(3):670-676.
9[5]FURUTA T,SAGEHASHI Y,SHIRAI N,et al.Influence of CYP2C19 polymorphism and Helicobacter pylori genotype determined from gastric tissue samples on response to triple therapy for H pylori infection[J].Clin Gastroenterol Hepatol,2005,3(6):564-573.
10[6]TOGAWA J,INAMORI M,FUJISAWA N,et al.Efficccy of a triple therapy with rabeprazole,amoxicillin,and faropenem as second-line treatment after failure of initial Helicobacter pylori eradication therapy[J].Hepatogastroenterology,2005,52 (62):645-648.
