摘要
目的 探讨苦参素联合复方丹参注射液对乙型肝炎活动性肝硬化的治疗效果。方法将42例乙型肝炎活动性肝硬化患者随机分为观察组和对照组。在常规治疗的基础上,观察组另给予苦参素400 mg肌注,复方丹参注射液14ml入液静脉滴注,每天1次;对照组采用常规治疗。然后观察肝功能、乙肝病毒标记物、肝纤维化指标的变化。结果 疗程结束及治疗结束5个月后,观察组肝功能指标ALT、AST、ALB、A/G、TBIL均较治疗前有显著改善(P<0.05或P<0.01);对照组仅ALT、AST有改善(P<0.05);HBV-DNA及HBeAg阴转率,观察组显著高于对照组(P<0.05);肝纤维化指标水平,观察组治疗后较治疗前显著下降(P<0.05),而且也显著低于对照组治疗后(P<0.05)。观察组少数患者出现腹泻和注射部位硬结。结论 苦参素联合复方丹参注射液能明显控制活动性肝硬化的炎症活动,抑制HBV复制,且具有抗纤维化的作用,无严重不良反应。
ObjectiveTo investigate the therapeutic; effects of Oxymatrine combined with compound Danshen injection on active cirrhosis related to chronic hepatitis B. Methods 42 patients with cirrhosis were enrolled and divided randomly into observation group and control group. All the patients received the basic treatment for active cirrhosis. Based on the basic treatment, the patients in observation group were given Oxymatrine combined with compound Danshen Injection in addition. The liver function , hepatitis B virus, the marker of hepatic fibrosis and side effects were observed and evaluated after one treatment course and five-month follow-up. Results The markers of liver function :ALT, AST, ALB,A/G,TBIL were Improved significantly in observation group ( P < 0.05 or P < 0.01), while only ALT and AST were improved significantly in control group ( P < 0.05). The negative rates of HBV-DNA and HBeAg in observation group were significantly higher than thane in control group ( P < 0.05 );The hepatic fibrosis indexes were improved significantly in observation group after treatment( P < 0,05),but which were not reduced significantly in control group.There were no severe side effects in both groups. Conclusion Oxymatrine combined with compound Danshen injection can effectively control the activity of inflammation of the patients with active chronic cirrhosis , reverse the deoompensated condition and inhibit the replication of hepatitis B virus, without seveve side effect for the patients.
出处
《疑难病杂志》
CAS
2003年第4期210-212,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
苦参素
复方丹参注射液
乙型肝炎
动性肝硬化
治疗
肝纤维化
Oxymatrine
Compound Danshen injection
Active cirrhosis
Liver function
Hepatitis B virus marker
Liver fibrosis
