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卡维地洛与细胞增殖及凋亡关系研究进展 被引量：3

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摘要 卡维地洛是新的第三代 β肾上腺素受体阻滞剂 ,具有α和 β受体阻断、钙拮抗、抗氧化、抗细胞增殖及抑制心肌细胞凋亡等作用。可用于高血压、动脉粥样硬化、充血性心力衰竭的治疗。
作者 张海涛 赵连友
机构地区 第四军医大学附属唐都医院心内科
出处 《高血压杂志》 CSCD 2003年第4期302-304,共3页 Chinese Journal of Hypertension
关键词 卡维地洛 增殖 凋亡
分类号 R965 [医药卫生—药理学]
  • 相关文献

参考文献16

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  • 2Lysko PG, Webb CL, Gu JL, et al. A comparision of carvedilol and metoprolol antioxidant activities in vitro[J] .J Cardiovasc Pharmacol, 2000,36 ( 2 ) : 277 - 281.
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二级参考文献15

  • 1周斌,魏尔清.β受体阻滞药卡维地洛[J].中国新药杂志,1996,5(1):23-26. 被引量：10
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  • 611，Fuerstein GZ,Ruffolo RR.Carvedilol,a novel vasodilating betablocker with the potential for cadiovasculor organ protection. Eur Heart J,1996,17(Suppl B) ∶S24
  • 712，Yue TL,Liu T,Fuerstein G.Carvedilol,a new vasodilator and beta-adrenocepto r antagonist,inhibits oxygen radical mediated peroxidation. in swine ventricula r menbranes. Pharmacol Comm， 1992,(1)∶27
  • 813，Yue TL,Ma XL,Gu JL. Carvedilol inhibits activation of stress－activated prot ein kinase and reduces reperfusion injury in perfused rabbet heart. Eur J Phar macol,1998,345(1)∶61
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  • 1015，Yue TL,Ma XL,Wang X,et al. Possible involvement of stress-activated pro tein kinase signaling pathway and Fas receptor expression in prevention of ische mia/reperfusion induced cardiomyocyte apoptosis by cardedilol. Circ Res,1998 ,82(12)∶166

共引文献11

同被引文献32

  • 1鹿庆华,董兆强,郝林,蒋卫东,王欣,徐冬玲.卡维地洛预防冠状动脉介入治疗后再狭窄的观察[J].中华心血管病杂志,2005,33(2):157-157. 被引量：12
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  • 4[3]Yue TL,Cheng HY, Lysko PG et al.Carvedilol,a new vasodilator and adrenocepter antagonist,is an antioxidant and free radical scavenger [J]. J Pharmacol Exp Ther,1992,263(1):92-98.
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  • 6[5]Xin LM,Bernard LL,Gao LL et al.Hypercholesterolemia impairs a detoxification mechamism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury[J].Circ Res,1997,80(6):894-901.
  • 7[6]Yue TL,Wang X,Gu JL et al.Carvedilol,a new vasodilating beta-adrenoceptor blocker,inhibits oxidation of low density lipoproteins by vascular smooth muscle cell and prevents leukocyte adhesion to smooth muscle cells[J].J Pharmacol Exp Ther,1995,273(3):1442-1449.
  • 8[7]Yue TL,Ma XL,Wang X et al.Possible involvement of stress-actived protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion induced cardiomyocyte apotosis by carvedilol[J].Cric Res,1998,82(12): 166-174.
  • 9[8]Rossing L,Mallat Z,Haendeler J et al.Congestive heart failure incluces endothelial cell apoptosis:protective role of carvedilol[J].J Am Coll Cardiol,2000,36(7):2081-2089.
  • 10[11]Schnee JM,Hsueh WA.AngtiotensinⅡ,adhesion ,and cardiac fribrosis[J].Cardiovasc Res ,2000,46(2):264-268.

引证文献3

二级引证文献10

高血压杂志
2003年 第4期

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