摘要
目的 :研究防风与刺蒺藜单用及合用的药理作用。方法 :运用右旋糖酐及组胺造成搔痒模型 ,组胺引起毛细血管通透性增高 ,二甲基亚砜引起接触性荨麻疹 ,观察药物作用。结果 :防风、刺蒺藜、防刺合煎剂对外源性组胺和右旋糖酐诱导内源性组胺动物搔痒模型均有显著的止痒作用 ,能明显抑制组胺引起的毛细血管通透性增高 ,能不同程度地抑制二甲基亚砜所致的豚鼠耳肿胀。结论 :防风、刺蒺藜、防刺合煎剂有抗过敏作用 。
Objective: To study the pharmacological effects of Radix Saposhnikoviae (RL) and Fruetus Tribuli (FI) used singly and combinedly. Methods: The effect of the tested drugs on the animal itching models induced by dextran 40 and Histanmine, skin capillary permeability induced by Histamine and experimental nettle rash induced by dimethylsulfoxide (DMSO) were observed. Results: RL and FI used singly and combinedly could obviously relieve the itch, inhibit the increase of skin capillary permeability induced by Histamine and resist experimental nettle rash induced by dimethylsulfoxide (DMSO) in different degree. Conclusion:RL and FI used singly and combinedly have anti allergic effect and the effect of RL and FI used combinedly is the same as used respectively.
出处
《中成药》
CAS
CSCD
北大核心
2003年第9期737-739,共3页
Chinese Traditional Patent Medicine
关键词
防风
刺蒺藜
止痒
抗过敏
小鼠
豚鼠
Radix Saposhnikoviae
Frutus Tribuli
relieve itching
anti allergic effect
mouse
guinea pig
