摘要
目的 :探讨迷尔永康膏 (黄连、苦参、蛇床子、紫花地丁等 )治疗阴道炎的药理作用。方法 :利用试管法体外抑菌试验 ,对豚鼠磷酸组胺致痒反应 ,二甲苯致小鼠耳廓急性炎症以及蛋清致大鼠足跖肿胀法 ,观察该药的抗菌、抗炎、止痒作用。结果 :迷尔永康膏对金黄色葡萄球菌、白色葡萄球菌、淋球菌、滴虫及艾滋病毒有显著的抑杀作用 ;明显提高豚鼠磷酸组胺致痒反应的痒阈值 ,减少小鼠二甲苯致耳郭炎症及大鼠蛋清足跖的肿胀度。结论 :迷尔永康膏具有明显的抑菌、抗病毒、抗炎及止痒作用。
Objective: The bacteriostatic, antiviral, anti inflammatory and antipruritic effects of Mieryongkang Ointment (Rhizoma Coptidis, Radix Sophorae Flavescentis, Fructus Cnidii, Herba Violae, etc) in the treatment of vaginitis were investigated. Methods: By the methods of tube bacteriostatic test in vitro, histamine phosphate allergic pruritic tolerance in guinea pig, xylene induced ear acute inflammatory oedema of mouse and egg albumin caused foot swelling of rat, the pharmacological effects were observed. Results: Mieryongkang Ointment could inhibit and/or destory staphylococcus aureus, staphylococcus albus, gonococcus, trichomonad and human immunodeficiency virus in tube trial. It also increased the itching threshold value of histamine phosphate allergic pruritic tolerance in guinea pig and decreased the rates of swelling in ear acute inflammatory oedema of mouse induced by xylene and egg albumin caused in foot of rat after using the drug in skin. Conclusion:Mieryongkang Ointment has bacteriostatic, antiviral, anti inflammatory and relieving the itch.
出处
《中成药》
CAS
CSCD
北大核心
2003年第9期731-734,共4页
Chinese Traditional Patent Medicine
关键词
迷尔永康膏
药理作用
阴道炎
豚鼠
大鼠
小鼠
Mieryongkang Ointment
pharmacological action
vaginitis
quinea pig
rat
mouse
