摘要
目的以异丙酚纳米乳剂为模型药 ,比较高斯曲线分布与Nicomp多波型分布分析在纳米分散系粒径测定中的应用。方法制备 2种处方不同 ,工艺相同的异丙酚纳米乳剂 (分别为Ⅰ及Ⅱ ) ,以激光Nicomp3 80系统分别测定Gaussian分布与Nicomp多波型分布下相应的动态光散射光谱。结果同一制剂 ,2个分布有显著差别。纳米乳剂Ⅰ 2种图谱示单峰 ;纳米乳剂Ⅱ 2种图谱不同 ,前者为单峰 ,而后者为双峰。结论对均匀分散系 ,2种分析通常产生可靠的结果 ,而对非均匀分散系 。
Objective To take propofol nanoemulsion as a modle and compare the applications of Gaussian and Nicomp distribution in the laser diffraction (LD) to particle size determination of ultra-fine dispersion.Methods Two preparations were named emulsion Ⅰ and emulsion Ⅱ respectively,by the same procedure while different recipes had been made.Their dynamic light scattering spectroscopy was measured by the Gaussian and Nicomp distribution analysis of Nicomp380 laser system.Results The single-peak appeared for emulsionⅠnot only in Gaussian,but also in Nicomp distribution.For emulsionⅡ,the former was one park,the latter showed double-peak.Conclusions For unimodal distributions,the method of cumulations usually yields reliable results.For more complex multimodal distributions,the Nicomp analysis is better.
出处
《沈阳药科大学学报》
CAS
CSCD
2003年第5期321-324,共4页
Journal of Shenyang Pharmaceutical University
