摘要
目的以乙基纤维素和硬脂酸为骨架材料 ,采用挤出滚圆法制备氢溴酸右美沙芬骨架缓释微丸。方法以圆整度和释放度为评价指标 ,先对工艺因素 (挤出速度 ,滚圆速度 ,滚圆时间及热处理温度 )和处方因素 (乙基纤维素与硬脂酸的比例 ,微晶纤维素的用量 ,润湿剂的用量 )进行了单因素考察 ,然后进一步采用正交设计对其优化。结果优化条件所得缓释微丸外观圆整 ,粒子大小分布均匀 ,具有明显的缓释特性。结论通过以上处方和工艺可以制备具有 1
Objective To prepare sustained-release pellets by extrusion-spheronisation with the matrix material of ethyl cellulose and stearic acid. Method The effects of process variables and formulation variables on pellets preparation and drug release were investigated. The formulation and preparation process of dextromethorphan hydrobromide sustained-release matrix pellets were optimized. Results The sustained-release matrix pellets had a marked sustained-release property. Conclusion It is possible to prepare sustained-release pellets by extrusion-spheronisation with ethyl cellulose and stearic acid as the matrix materials without the need to coat the pellets.
出处
《沈阳药科大学学报》
CAS
CSCD
2003年第5期313-320,324,共9页
Journal of Shenyang Pharmaceutical University
关键词
氢溴酸右美沙芬
骨架缓释微丸
挤出滚圆法
dextromethorphan hydrobromide
matrix sustained-release pellets
extrusion-spheronisation
