摘要
目的 :观察米索前列醇配伍催产素用于剖宫产预防产后出血的效果。方法 :选择 4 2 0例剖宫产随机分组米索前列醇 +催产素组、米索前列醇组及催产素组。米索前列醇 +催产素组 (180例 )。术中破膜后立即口服米索前列醇 4 0 0ug ,胎儿娩出后立即宫体肌内肌注催产素 2 0IU ,米索前列醇组 (14 0例 ) ,于术中破膜后立即口服 6 0 0ug米索前列醇 ,催产素组于胎儿娩出后立即宫体肌内注射 2 0IU催产素再静脉注射 2 0IU催产素 ,以上各组观察术后 2h出血量。结果 :术后 2h平均出血量米索前列醇 +催产素组 2 10± 5 2 .4ml,米索前列醇组 2 2 0± 5 6 .2ml,催产素组为 36 1± 35 .6ml,米索前列醇 +催产素组与米索前列醇组差异无显著性 (P <0 .0 1) ,米索前列醇 +催产素组与催产素组差异有极显著性 ,但单用米索前列醇 6 0 0ug有副作用。结论 :米索前列醇 +催产素组促进子宫收缩强于催产素组。能较好地预防剖宫产术后出血 ,且无明显副反应 ,用药方便 ,适合推广。
Objective:To observe the effects of misoprostol with oxytocin on the reduction of postpartum bleeding in and after cesarean section.Methods:Four hundred and twenty cesarean sections were randomized into three groups: misoprostol group(n=140),600μg misoprostol was given orally when the membrane was ruptured;misoprostol and oxytocin group (n=180),400μg misoprostol was given orally when the membrane was ruptured and 20 IU oxytocin was injected into uterine muscle immediately after delivery of baby. Oxytocin group(n=100),20IU oxytocin was injected into uterine muscle and 20 IU intravenous injected immediately after delivery of baby. The amount of bleeding within 2 hours after delivery was measured.Results:The mean amount of bleeding in misoprostol group was 220±56.2ml,in misoprostol and oxytocin group was 210±52.4ml,oxytocin group was 361±35.6ml,respectively. The difference was significant ( P <0.01) between misoprostol plus oxytocin group and oxytocin group,and there was no differences between misoprostol group and misoprostol plus oxytocin group.But there are certain side effects by only using misoprostol.Conclusion:Misoprostol and oxytocin are more effective in the reduction of postpartum bleeding than oxytocin.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第12期68-70,共3页
China Journal of Modern Medicine
关键词
剖宫产产后出血
米索前列醇
催产素
Cesarean Section
Postpartum Hemorrhage
Misoprostol
Oxytocin
