摘要
目的:探讨青年长期吸烟血管内皮依赖性舒张功能的改变。方法:测定20例长期吸烟青年及15例正常对照者血流介导的和硝酸甘油介导的肱动脉内径改变。结果:两组肱动脉内径基础值(3.75±0 61mm:3.81±0.55mm)及硝酸甘油介导的肱动脉舒张[(22.13±7.65)％:(23.45±8.21)％]无显著差异(P>0.05),而血流介导的血管扩张存在显著差异.为[(3.61±2.90)％:(8.32±4.75)％]、P<0.01。单因素相关分析表明,肱动脉内皮依赖件舒张与吸烟量呈显著负相关(r=0.523.P<0.001).结论:青年长期吸烟者血管内皮依赖性舒张功能明显受损,受损程度与吸烟量有关。
Objective: To study the change of endothelium-dcpendent dilatation function of brachia! artery in young long term smokers. Methods: The internal diameters of brachial arteries of flow-mediate (FMD) and glyceryl trinitrate-induced (GTN-induced) were measured in 20 cases young long-term smokers and 15 controls (no smoking). Results: The basic internal diameter of brachial artery and GTN-induced dilatation of brachial artery had no difference (P>0. 05) while FMD dilatation had significantly difference [ (3. 61±2.90)% : (8. 32 + 4. 75)%] ( P<0. 01). Endothelium-dependent dilatation of brachial artery was negatively associated with quantity of cigarette. Conclusion: The function of endotheiium-dependent dilatation of brachial artery in young long-term smokers is significantly damaged and their damage degree is significantly correlation with quantity of cigarette.
出处
《心血管康复医学杂志》
CAS
2003年第4期292-294,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
