摘要
目的 :研究人乳头瘤病毒 (HPV) 16型和 18型感染与宫颈癌的关系。方法 :采用荧光探针PCR技术对 6 2例患者的宫颈管分泌物中HPV病原体分别进行检测 ,其中宫颈癌 2 2例 (包含CINⅢ级 10例 ) ;慢性宫颈炎 2 0例 ;正常宫颈 2 0例。结果 :上述宫颈分泌物中的HPV16、HPV18总阳性率分别是 5 9 1%、2 0 0 %和 0 %,三者差异具有显著性 ,且CINⅢ级与宫颈癌Ⅰ～Ⅲ期之间差异显著。结论 :HPV16、HPV18感染是宫颈癌致病的重要因素。HPV16、HPV18荧光探针PCR技术可以作为检测HPV16、HPV18感染及宫颈癌早期诊断标记之一。
Objective:To investigate the relationship between cervical carcinoma and infection of Human papillomavirus type-16 and 18.Methods:HPV expression in the secretion of cervical cancer, chronic cervicitis or normal cervical is detected by fluorescence polymerase chain reaction diagnostic kit.Results:The total positive rate of HPV-16,18 in the secretion of cervical cancer, chronic cervicitis or normal cervical are 59.1%, 20.0%,0% respectively. The difference is markedly significant. And the difference of HPV positive rate between CIN-Ⅲand cervical cancer (stageⅠ～Ⅲ) is also significant.Conclusion:This study indicated that the infection of HPV-16,18 is one of the important factors in the development of cervical carcinoma. Fluorescence polymerase chain reaction diagnostic technic maybe an effective method in detection of HPV-16,18 infection for early cervical carcinoma.
出处
《临床肿瘤学杂志》
CAS
2003年第4期274-275,共2页
Chinese Clinical Oncology
关键词
人类乳头瘤病毒
宫颈癌
早期诊断
相关性
病原体
Human papillomavirus(HPV)
Cervical carcinoma
Relationship
Early diagnose
