摘要
目的 评价哌拉西林 /他唑巴坦 (特治星 )治疗神经外科术后感染的疗效与安全性。方法 采用神经外科术后颅内感染的病例 35人 ,其中颅内肿瘤术后感染 10人 ,颅脑损伤术后感染 2 0人 ,侧脑室腹腔分流术 (V P分流术 )后感染 5人 ,给药方案为生理盐水 +哌拉西林 /他唑巴坦 4 .5 g ,静脉点滴 ,每 8h1次 ,3次 /d ,每次持续约1h ,疗程 2～ 3周。结果 哌拉西林 /他唑巴坦治疗神经外科术后颅内感染总有效率为 97.1% ,细菌消除率94 3% ,不良反应发生率为 2 .7% ,为轻度腹泻。结论 哌拉西林 /他唑巴坦治疗神经外科术后颅内感染疗效确切 ,不良反应少 ,值得推荐该药在神经外科应用。
OBJECTIVE To evaluate the efficacy and safety of piperacillin/tazobactam in the treatment of postoperative intracranial infections in neurosurgery. METHODS A total of 35 neurosurgical patients with postoperative intracranial infections were treated with piperacillin/tazobactam. Of 35 patients,ten were intracranial infections after intracranial tumor operation,twenty were intracranial infections after craniocerebral injury operation and five were intracranial infections after ventricular peritoneum shunt operation. The treatment regimen of piperacillin/tazotactam was 4.5g +N.S.250ml intravenous infusion every 8h for 2 3weeks. RESULTS The overall clinical efficacy rate of piperacillin/tazobactam was 97.1%(34/35).The bacterial clearance rate was 94.3%(33/35).The adverse reaction rate was 2.7%(1/35). CONCLUSIONS Piperacillin/tazobactam is effective and safe in the treatment of postoperative intracranial infections in neurosurgery.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第8期744-746,共3页
Chinese Journal of Nosocomiology
