摘要
目的 :分析 β 内酰胺类抗生素所致肾损害的药物品种、常见临床特点及可能原因。 方法 :以 1 996～2 0 0 2年 6月中国生物医学文献数据库和Medline中有关 β 内酰胺类抗生素所致肾损害的文摘为线索 ,逐篇查阅原文 ,按统一标准筛选病例 ,并进行统计分析。结果 :6年间符合筛选标准的 1 1 3篇文献中报告 β 内酰胺类抗生素所致肾损害 345例 ,共涉及 1 6种药物 ,其中头孢菌素类占 32 1例 ,达 93 .0 4 % ,主要为头孢拉定、头孢唑林和头孢地嗪 ;青霉素类仅 2 4例 ,占 6 .96 % ,常见为氨苄西林和阿莫西林。肾损害临床表现主要为血尿 (2 86例 ) ,以头孢菌素类所致为主 (98.60 % )。其次为急性肾衰竭 52例 ,青霉素类所占比例较高 (66 .67% )。本文分别对头孢菌素类和青霉素类所致的血尿和急性肾衰竭临床特点、药物致病因素和预防措施进行了分析。结论 :合理用药、适时监测尿常规和肾功能变化应可减少或避免 β
Objective: To investigate the sorts of drugs and common clinical characteristics of β lactams antibiotics induced renal damage, and further analyze the influence factors related to renal damage.Method: The articles involved inβ lactams antibiotics induced renal damage in the database of Chinese Biomedical Disc and Medline from 1996 to June, 2002 were reviewed and analyzed.Result: There were 113 articles reporting 345 cases concerningβ lactams antibiotics induced renal damage in the period of 6 years. The cases were caused by 16 kinds of drugs, among which, 327 cases were caused by cephalosporins( 93.04% ). The main drugs were cefradine, cefazolin and cefodizime. The other 18 cases were caused by penicillins ( 6.96% ), mainly including ampicillin and amoxillin. The clinical manifestations of renal damage were hematuria(286 cases), in which cephalosporins accounted for 98.6% . Acute renal failure was also found in 52 cases, in which penicillins accounted for 66.67% .Conclusion: To preventing fromβ lactams antibiotics induced renal damage, the dugs should be rationally used, and urine or renal function have to be regularly monitored.
出处
《药物流行病学杂志》
CAS
2003年第4期198-201,共4页
Chinese Journal of Pharmacoepidemiology
