摘要
目的 :为探讨血管内皮生长因子 (VEGF)、淋巴细胞分化抗原 (CD4 4v6 )及细胞核增殖抗原 (Ki6 7)在非小细胞肺癌(non -smallcelllungcarcinoma ,NSCL)组织中的表达。 方法 :采用SP免疫组织化学方法观察VEGF、CD4 4v6及Ki6 7在 6 2例NSCLC组织的表达。结果 :VEGF、CD4 4v6及Ki6 7在NSCLC组织中阳性表达率均明显高于癌旁正常组织 ,P <0 .0 1,它们的表达与临床分期及有无淋巴结转移有明显相关 ,Ⅲ -Ⅳ期NSCLC组织中此 3项指标均明显高于Ⅰ -Ⅱ期 ,有淋巴结转移组其阳性率明显高于无淋巴结转移组 ,P <0 .0 5 ;VEGF、CD4 4v6及Ki6 7阳性的患者 3年生存率均明显低于阴性者。结论 :通过这 3个指标的检测 ,可以判断和预测NSCLC患者的预后及指导其临床治疗。
Objective:To investigate the expressions of VEGF, CD44v6 and Ki67 in non-small cell lung carcinoma.Methods:The expressions of VEGF,CD44v6 and Ki67 in NSCLC tissue of 62 cases were studied by immunohistochemical staining.Results:All the positive rates were higher than matched normal lung tissues, P <0.01.Their expressions were related to clinical stages and the metastasis of lymph nodes.The expression rates of the three markers in NSCLC with the metastasis of lymph nodes were higher than those without metastasis,and the expressions of the three markers in Ⅲ-Ⅳ stages were higher than those in Ⅰ-Ⅱ stages, P <0.05.Survival rates of three years were lower among those patients with the positive expressions of these three markers than those with the negative expressions, P <0.05.Conclusion:The expression testing of the three markers may help in prediction of prognosis and clinical guidance for NSCLC patients.
出处
《重庆医科大学学报》
CAS
CSCD
2003年第4期473-476,共4页
Journal of Chongqing Medical University
