摘要
目的 探讨原发性高血压 (EH)病人左室舒张功能与血清瘦素 (Leptin)浓度的关系。 方法 采用放免法测定 30例正常人和 5 4例EH病人的血清瘦素浓度。用多普勒组织成像 (DTI)技术检测正常人及EH病人二尖瓣环舒张早期运动速度 (Ea)、舒张晚期运动速度 (Aa)及Ea/Aa ,比较其测值与血清瘦素浓度的相关性。结果 EH病人组二尖瓣环DTI参数明显低于正常对照组 (P <0 0 1) ;EH病人组血清瘦素浓度与Ea、Ea/Aa呈负相关 (r =- 0 4 1,P <0 0 1;r =- 0 4 3,P <0 0 1)。
Objective To explore the relationship between left ventricular diastolic function in patients with essential hypertension(EH) and the serum concentration of leptin.Methods Fifty four EH patients and 30 normotensive control subjects were enrolled and the serum concentratiln of leptin in the two groups were measured by spectic radioimmunoassays.Mitral annular velocity in early diastole(Ea) and late diastole(Aa) in normal and EH patients by were studied doppler tissue imaging(DTI) and the correlation between these doppler indexes and the serum concentration of leptin was compared.Results The Ea and Ea/Aa in EH patients were lower than those in controls(P<0.01).Serum concentration of leptin were negatively correlated with Ea and Ea/Aa in EH patients(r=-0.41,P<0.01;r=-0.43,P<0.01).Conclusion Measurement of serum concentration of leptin can evaluate the severity of left ventricular dysfunction in EH patients.
出处
《中国基层医药》
CAS
2003年第7期593-594,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
河南省科技攻关项目(0 2 2 463 0 15 1)
