摘要
目的 对大蒜粗提物作为保健食品的降脂减肥作用进行评价 ,并初步研究其作用机理。方法 选用SD雄性大鼠 ,建立高血脂和肥胖模型 ,以卫生部《保健食品功能学评价程序和检验方法》为实验依据。结果 大蒜粗提物 0 2、 0 4和 1 2g/kgB W 剂量组能明显降低高血脂大鼠血清胆固醇 (TC)含量 :0 4和1 2g/kgB W 剂量组能明显降低高血脂大鼠血清甘油三脂 (TG)含量 ,同时也明显降低肥胖大鼠的体重、增重和体内脂肪湿重 ;1 2g/kgB W 剂量组能明显降低肥胖大鼠的体脂比。结论 大蒜粗提物具有降脂减肥作用 ,其机理可能与调节机体脂质代谢有关。
Objective To evaluate the effect of raw garlic extract on the lipid lowering and weight losing,and to study the mechanism of it primarily.Methods According to the 'procedusres and methods of functional evaluation for health food'by Ministry of Health,the SD rats were selected to setup animal models of high blood lipid and obesity respectively.Results The concentration of toal cholesterol(TC)in rat serum could be reduced with the dosed of 0 2,0 4 and 1 2g/kgB W of raw garlic extract,and the raw garlic extract of 0 1 and 1 2g/kgB W could also dectrease the concentration of triglyceride(TG)and the weight as well as the increased weight and the wet weight of fat in the rat.The ratio of weight and fat was reduced in rats with the dose of 1 2g/kg B W.Conclusions Raw garlic extract has a lipid lowering and weight losing effects on rats of high blood lipid and obesity,and the mechanism maybe related to the lipid metabolism
出处
《浙江预防医学》
2003年第8期14-16,共3页
Zhejiang Journal of Preventive Medicine
