摘要
目的 比较利培酮与氯氮平治疗对精神分裂症患者生活质量的影响。方法 随机抽取 30例服用利培酮、30例服用氯氮平的精神分裂症患者 ,出院 3个月时用生活质量综合评定问卷 (GQOLI)评估患者的生活质量 ,用阳性症状和阴性症状量表 (PANSS)、不良反应量表 (TESS)评定疗效与副反应。结果 利培酮组GQOLI评分显著高于氯氮平组 (P <0 .0 1) ,TESS评分显著低于氯氮平组 (P <0 .0 1) ,PANSS评分两组差异无显著性 (P >0 .0 5 )。结论 利培酮和氯氮平相比 ,更能提高患者的生活质量 。
Objective To compare the life quality of schizophrenia treated with risperidone and clozapine.Methods Sixty patients were randomly divided into risperdone group ( n =30) and clozapine group ( n =30).At the third month after discharge,all patients were assessed with the general quality of life inventory (GQOLI).The clinical efficacy and side effects were evaluated with the positive and negative symptom scale (PANSS) and the treament emergent symptom scale (TESS).Results The score of GQOLI was significantly higher in risperidone group than that in clozapine group,while the score of TESS was significantly lower in risperidone group than that in clozapine group and the score of PANSS was not significantly different between two groups.Conclusion Risperidone was superior to clozapine in improving the quality of life of schizophrenia and had an advantage in maintenance treament.
出处
《山东精神医学》
2003年第3期149-150,共2页
Shangdong Archives of Psychiatry
