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核素炎症显像的研究进展 被引量：2

The development of radionuclide imaging of infection and in flammation
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摘要 核素炎症显像是早期检测炎性病灶的一项重要手段。核素标记白细胞显像探测急、慢性炎症病灶灵敏度高,特异性强,素有“金标准”之称,但其标记过程复杂,又易发生交叉感染。一些替代性炎症显像的研究已获发展。本文简述了目前主要的核素炎症显像的特点和研究进展。 Radionuclide imaging of infection and inflammation is a powerful diagnostic tool in the management of pa-tients with infectious or inflammatory disease.Because of the excellent performance,radiolabeled leukocytes have be-come a gold standard nuclear medicine technique to image infection and inflammation.However,the preparation of this radiopharmaceutical is laborious and requires the handling of potentially contaminated blood.A few other methods are available that could be used instead of radiolabeled leukocytes imaging.In this article,the characteristics and diagnostic potential of established and experimental scintigraphic methods of infection and inflammation are reviewed.
作者 陈璟 吴华
机构地区 华中科技大学同济医学院附属同济医院核医学科
出处 《国外医学（放射医学核医学分册）》 2003年第3期107-110,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 炎症 核素显像 研究进展 核秦标记 scintigraphic imaging imfection and inflammation radiopharmaceuticals
分类号 R817.4 [医药卫生—影像医学与核医学] R364.5 [医药卫生—病理学]
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参考文献17

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同被引文献13

  • 1Bleeker-Rovers CP,Boerman OC,Rennen HJ,et al.Radiolabeled compounds in diagnosis of infectious and inflammatory disease[J].Curr Pharm Des,2004,10(24):2935-2950.
  • 2Hughes DK.Nuclear medicine and infection detection:the relative effectiveness of imaging with ^111In-oxine-,^99mTc-HMPAO-,and ^99mTc-stannous fluoride colloid-labeled leukocytes and with 67Ga-citrate[J].J Nucl Med Technol,2003,31(4):196-201.
  • 3Lupetti A,Welling MM,Pauwels EK,et al.Radiolabeled antimicrobial peptides for infection detection[J].Lancet Infect Dis,2003,3(4):223-229.
  • 4Yapar Z,Kibar M,Yapar AF,et al.The efficacy of technetium-99m ciprofloxacin(Infecton)imaging in suspected orthopaedic infection:a comparison with sequential bone/gallium imaging[J].Eur J Nucl Med,2001,28(7):822-830.
  • 5De Winter F,Vande Wiele C,Dumont F,et al.Biodistribution and dosimetry of ^99mTc-ciprofloxacin,a promising agent for the diagnosis of bacterial infection[J].Eur J Nucl Med,2001,28(5):570-574.
  • 6Bleeker-Rovers CP,Boerman OC,Rennen HJ,et al.Radiolabeled compounds in diagnosis of infectious and inflammatory disease[J].Curr Pharm Des,2004,10(24):2935.
  • 7Lupetti A,Welling MM,Pauwels EK,et al.Radiolabeled antimicrobial peptides for infection detection[J].Lancet Infect Dis,2003,3(4):223.
  • 8Brouwers AH,Laveramn P,Boerman OC,et al.A ^99mTc-labelled leukotriene B4 receptor antagonist for scintigraphic detection of infection in rabbits[J].Nucl Med Commun,2000,21:1043.
  • 9Sonmezoglu K,Sonmezoglu M,Halac M,et al.Usefulness of ^99mTc-ciprofloxacin scan in diagnosis of chronic orthopedic infection:comparative study with 99mTc-HMPAO leukocyte scintigraphy[J].J Nucl Med,2001,42:567.
  • 10De Winter F.Biodistribution and dosimetry of ^99mTc-ciprofloxacin,a promising agent for the diagnosis of bacterial infection[J].Eur J Nucl Med 2001,28(5):570.

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国外医学（放射医学核医学分册）
2003年 第3期

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