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左向右分流型先天性心脏病患儿血浆肿瘤坏死因子-α、T细胞亚群变化的临床意义 被引量:3

Correlative study on tumor necrosis factor and T-cell subset of children with congenital heart disease
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摘要 目的 通过对左向右分流型先天性心脏病 (先心病 )患儿血浆肿瘤坏死因子 α(TNF α)及T细胞亚群的研究 ,探讨细胞因子及细胞免疫在先心病心衰中发生发展的意义。方法 对 2 7例先心病心衰患儿、2 0例先心病非心衰患儿及 2 0例正常儿童采用双抗体夹心检测TNF α、荧光免疫ABC染色计算CD3、CD4、CD8及CD4 /CD8比值。结果 先心病心衰组TNF α含量明显高于非心衰组及对照组 ,且在心功能各级间存在显著性差异 (P <0 .0 1) ;重度心衰组CD3、CD4、CD8均低于正常组 (P <0 .0 1)。结论 TNF α参与先心病心衰的发展过程 。
作者 孟晓慧 汪翼
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2003年第7期525-526,共2页 Journal of Applied Clinical Pediatrics
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  • 1李树政.小儿心力衰竭专题座谈会纪要[J].中华儿科杂志,1985,23:293-295.
  • 2王立光,刘兴洲,张仕东,李珂静,吴军.脑瘫患儿血浆白细胞介素6、肿瘤坏死因子α含量变化[J].实用儿科临床杂志,1999,14(1):23-23. 被引量:1
  • 3Ross RD,Daniels SR,Schwartz DC,et al. Plasma norepinephrine levels in irdants and children with congestive heart failure[J ]. Am J Cardiol,1987;59:911.
  • 4Li YY, Feng YQ, Kadokami T, et al. Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor-α can be modulated by anti-tumor necrosis factor-α therapy [ J ]. Proc Natl Acad Sci USA,2000;97(23) : 12746-- 12751.
  • 5Torre-Amione G,Kapadia S,Lee J,et al Tumor necrois factor-α and tumor necrois factor receptors in the failing human heart[J]. Circulation, 1996; 93 : 704.
  • 6Kapadia S,Torre-Amione G, Yokoyama T, et al. Soluble TNF binding proteins modulate the negative inotropic properties of TNF-α invirro[ J ]. Am J Physiol, 1995 ; 268: H517.

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  • 1徐敬,舒礼良,赵文增,杨栋.婴幼儿围体外循环期肿瘤坏死因子-α、白细胞介素-8、白细胞介素-10的变化[J].实用儿科临床杂志,2004,19(7):597-598. 被引量:5
  • 2Ryhanen P, Huttunen K, Ilonen. Natural killer cell activity after open heart surgery[J]. Acta Anaesthesiol Scand, 1984,28:490.
  • 3RAKESH S, AIDAN P, BOLGER, et al. Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adult with congenital heart disease [J]. AmJ Cardiol, 2003,92:188-193.
  • 4LEVINE B, KALMAN J, MAYER L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure[J] . N Engl J Med, 1990, 323: 236-241.
  • 5MCMURRAY J, ABDULLAH I, DARGIE H J, et al. Increased concentrations of tumor necrosis factor in "cachectic" patients with severe chronic heart failure[J]. Br Heart J, 1991, 66:356-358.
  • 6TORRE-AMIONE G, KAPADIA S, BENEDICT C, et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD)[J]. J Am CollCardiol, 1996, 27: 1201-1206.
  • 7FERRARI R, BACHETTI T, CONFORTINI R, et al. Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure[J]. Circulation, 1995, 92:1479- 1486.
  • 8KUBOTA T, MCTIERNAN C F, FRYE C S, et al. Dialated cardiomopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor alpha[J]. Circ Res, 1997, 81:627-635.
  • 9BORISHL, AARONS A, RUMBYT J, et al. Interleukin-10 regulation in normal subjects and patients with asthma[J]. J Allergy Clin Immunol, 1996, 97: 1288-1289.
  • 10GULLESTAD L, AASS H, FJELD J G, et al. Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure[J]. Circulation, 2001,103:220-225.

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