摘要
应用组化ABC技术对87例伴有肠上皮化生(肠化生)的不同胃粘膜病变(慢性浅表性胃炎,慢性萎缩性胃炎,轻、中、重度异型增生,胃癌旁粘膜)组织中的菜豆凝集素(PHA)、双花扁豆凝集素(DBA)、花生凝集素(PNA)和刀豆凝集素(ConA)受体进行观察,并使用相同技术与正常胃粘膜(10例)和浸润进展型胃癌(16例)进行对比。结果,各病变组织中,四种凝集素表达的阳性率、反应强度及模式与组织学类型、分化程度有关。PHA、PNA和DBA的反应强度从正常胃粘膜、肠化生、异型增生到胃癌呈递增趋势,ConA呈递减趋势。染色模式:ConA以Ⅰ型为主;PNA以Ⅱ型为主;PHA和DBA以Ⅲ型为主。
4 kinds of lectin receptors (PHA, DBA, PNA, ConA) in the tissues of a variety of lesions of the gastric mucosa are studied with the histochemical method (ABC technique) in 87 cases. The results are follows: the positive rates of 4 kinds of lectin-binding, the distribution of lectin receptors, the intensity of positiveness and the stained patterns are correlated to the histologic types and the grades of various mucosal lesions. The intensity of positive reaction of PHA, PNA and DBA shows a progressive rising, while that of ConA appears a gradual declining tendency with the change from normal gastric mucosa to intestinal metaplasia and cancer. The stained patterns of lectin are: type I is the main pattern for ConA, type I for PNA and type III for PHA and DBA .
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第6期415-418,共4页
Medical Journal of Chinese People's Liberation Army
关键词
肠上皮化生
胃肿瘤
胃粘膜
Lectin
Histochemistry
Intestinal metaplasia
Dysplasia
Gastric cancer
