摘要
对哮喘11例患者和12名正常人进行支气管肺泡灌洗(BAL),两组BAL液中细胞总数和各细胞百分率包括肺泡巨噬细胞(AM)、淋巴细胞、嗜中性与嗜酸性粒细胞无显著差异。体外培养条件下,粉尘螨(DPF)抗原激发后,哮喘者AM释放前列腺素E(PGE)的量明显增加。哮喘者AM经DPF特异性IgE阳性血清致敏及DPF激发,释放PGE前列腺素F_(2a)(PGF_(2a))均较DPF特异性阴性血清及DPF激发组显著增加(P<0.01),PGE/PGF_(2a)比值明显下降,并与患者MCH-PC_(20)值明显正相关。结果表明,哮喘者AM在特异性IgE及抗原作用下释放PGE、PGF_(2a)量的不同,乃至PGE/PGF_(2a)比值下降对哮喘发病起重要作用。BAL用于稳定性哮喘患者较为安全。
Bronchoalveolar lavage (BAL) was performed in healthy subjects (n = 12) and patients with bronchial asthma (n = ll). Between two groups there were no significant differences in total cells and percentage of alveolar macrophages (AM), lymphocytes, ncutrophils, cosinophils in BAL fluids. When AM were cultured in vitro and stimulated with dermatophagoides farinae(DPF) antigen, the quantity of PGE released by AM was significantly increased in asthmatics. When asthmatics' AM were sensitized with specific IgE positive serum and stimulated with DPF, they released more PGE, PGF2a than that when specific IgE negative serum was used (P<0.01). The PGE/PGF2a rate was significantly decreased. There was positive correlation between the decreased value of PGE/PGF2a and patients' MCH-PC20. The increase in PGE and PGF2a released and the decrease in PGE/PGF20 ratio might play an important role in the pathogenesis of allergic asthma. The examination of BAL was relatively safe to be used for stable allergic asthmatics.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第4期268-271,共4页
Medical Journal of Chinese People's Liberation Army
关键词
哮喘
前列腺素E
肺泡
巨噬细胞
Asthma
Prostaglandin E
Prostaglandin F2a
Alveolar macrophagcs
