摘要
应用蜗内电位(EP)、听神经动作电位(AP)同步记录技术观察了前列腺素(PGs)合成抑制剂消炎痛对于速尿耳蜗毒性的影响。速尿加消炎痛组EP(mV)和AP_(N1)相对振幅(％)下降程度均低于单纯速尿组,电位恢复速率则明显大于速尿组。实验提示速尿对耳蜗靶组织血管纹的损伤与PGs介导有关。消炎痛对抗速尿的作用机理可能在于抑制了耳蜗内源性PGs的生物合成,因而减轻了速尿对EP及AP_(N1)的抑制效应。
We have observed the protective effects of indocin (IND), a potent inhibitor of pro-sglandins (PGs), on ototoxicity induced by furosemide (FU) using the synchronous recording technique of endocochlear potential (EP) and auditory action potential(AP) in guinea pigs. The FU group were found to have a mean decrease in EP of 65.1±5.6mV and AP amplitude 91.5±10.2%. In contrast, the animals in the FU+IND group had a much smaller reduction of EP(17.5 ±3.8mV) and AP amplitude(31.1±4.7%). The rate of return in EP and AP was much faster in the FU+IND group as compared with the other group. Our findings suggest that the ototoxicity of FU may be related to the mediation of PGs in the inner ear target tissues. IND can interrupt an increase in endogenous PGs in cochlear tissues triggered by FU injection by inhibiting the biological synthesis of PGs, thus effectively diminishing the ototoxicity induced by FU.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第3期200-203,共4页
Medical Journal of Chinese People's Liberation Army
关键词
速尿
耳毒性
蜗内电位
消炎痛
PGs synthetic inhibitor
Furosemide
Ototoxicity
Endocochlear potential
Auditc action potential
