摘要
检测了左向右分流型先天性心脏病51例患儿血浆免疫活性心房利钠多肽(ir-ANP)、环磷酸乌苷(cGMP)、血管紧张素Ⅱ(ATⅡ)水平及肾素(PRA)和血管紧张素转化酶(ACE)活性。结果显示,先天性心脏病组血浆ir-ANP、cGMP、ATⅡ,ACE较对照组明显增高(P<0.01),PRA则无显著差异(P>0.05)。血浆ir-ANP,ATⅡ水平还与心脏缺损直径大小以及平均肺动脉压力正相关(P<0.05)。结果提示,左向右分流型先天性心脏病时ACE活性增加,血浆ATⅡ水平因而升高,促进肺动脉高压。ANP代偿性分泌增多则阻抑ATⅡ效应。
Plasma levels of immunoreactive atrial natriurtic polypeptide(ir-ANP), cyclic guano-sin monophosphate(cGMP), angiotensin Ⅱ (ATⅡ) and activity of plasma renin (PRA) and serum angiotensin converting enzyme (ACE) were measured in 51 children with congenital heart disease (CHD) mith left to right shunt. The result of present work showed that the children with CHD had higher levels of ir-ANP, cGMP, ATⅡ and activity of ACE than controls (P<0.01). The plasma levels of ir-ANP and ATⅡ were correlated not only with diameter of the cardiac defect but also with mean pulmonary presure (P<0.05). The above results suggested that in CHD with left to right shunt the increasing pulmonary blood flow and volume resulted in higher activity of ACE and rising plasma levels of ATⅡ, promoting pulmonry hypertention. Increased ANP inhibited the action of ATⅡ.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第3期187-189,共3页
Medical Journal of Chinese People's Liberation Army
关键词
先天性心脏病
心钠素
血管紧张素
Congenital heart disease
Atriai natriuretic polypeptide
Angiotensin II
Activity of plasma renin
